Research Spotlight - January 2022

We’re excited to present our first Research Spotlight edition of 2022, which features the latest scientific innovations from researchers whom Boster has served.

In this issue, scientists explore the signaling mechanisms of GDF11 during aging, TAF7 during gene expression, OTUD1 in intestinal inflammatory diseases, and the m6Am mRNA in the regulation of obesity.

We have also highlighted several studies discussing novel strategies in nanomedicine to help advance modern healthcare, including the GMDA hydrogel for wound healing, bilirubin-based nanoparticles for topical skin treatment, and the metal–organic nanovesicles loaded with glycyrrhizic acid that exhibit potent anti-inflammatory properties.

Be sure to scroll down to learn about the research studies!

The Nuclear Transcription Factor, TAF7, is a Cytoplasmic Regulator of Protein Synthesis

Authors: Cheng, D., Semmens, K., McManus, E., Chen, Q., Meerzaman, D...
Journal: Science Advances

The TFIID component, TAF7, has been extensively characterized as essential for transcription and is critical for cell proliferation and differentiation. Here, we report that TAF7 is a previously unknown RNA chaperone that contributes to the regulation of protein synthesis. Mechanistically, TAF7 binds RNAs in the nucleus and delivers...

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Cited Boster Product(s): Anti-CRM1 XPO1 Antibody Picoband™ (Monoclonal, 5G3) (M01180)

A Facile Low-Dose Photosensitizer-Incorporated Dissolving Microneedles-Based Composite System for Eliciting Antitumor Immunity and the Abscopal Effect

Authors: Bian, Q., Huang, L., Xu, Y., Wang, R., Gu, Y., Yuan, A., Ma, X., Hu, J...
Journal: ACS Nano

Nanomedicine-based photodynamic therapy (PDT) for melanoma treatment has attracted great attention. However, the complex design of polymer nanoparticles and high doses of photosensitizers used in intravenous injections (for sufficient accumulation of drugs in tumor lesions) pose a huge challenge to the commercialization and further...

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Cited Boster Product(s): Mouse IFN Gamma / IFNG / Interferon Gamma ELISA Kit PicoKine™ (EK0375)

Dynamic Regulation of N6,2′-O-Dimethyladenosine (m6Am) in Obesity

Authors: Ben-Haim, M.S., Pinto, Y., Moshitch-Moshkovitz, S., Hershkovitz, V...
Journal: Nature Communications

The prevalent m6Am mRNA cap modification was recently identified as a valid target for removal by the human obesity gene FTO along with the previously established m6A mRNA modification. However, the deposition and dynamics of m6Am in regulating obesity are unknown. Here, we investigate the liver m6A/m methylomes in mice fed on a...

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Cited Boster Product(s): Anti-Intestinal FABP/FABP2 Antibody Picoband™ (PB9943)

Adaptively Evolved Human Oral Actinomyces-Sourced Defensins Show Therapeutic Potential

Authors: Zhu, S., Gao, B., Umetsu, Y., Peigneur, S., Li, P., Ohki, S., Tytgat, J.
Journal: EMBO Molecular Medicine

The development of eukaryote-derived antimicrobial peptides as systemically administered drugs has proven a challenging task. Here, we report the first human oral actinomyces-sourced defensin—actinomycesin—that shows promise for systemic therapy. Actinomycesin and its homologs are only present in actinobacteria and myxobacteria, and...

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Cited Boster Product(s): Human MCP-1 / CCL2 ELISA Kit PicoKine™ (EK0441)

Self-assembled Nanoparticles with Bilirubin/JPH203 Alleviate Imiquimod-Induced Psoriasis by Reducing Oxidative Stress and Suppressing Th17 Expansion

Authors: Jiang, X., Yao, Q., Xia, X., Tang, Y., Sun, M., Li, Y., Zheng, H., Cai, A...
Journal: Chemical Engineering Journal

Psoriasis is a chronic inflammatory skin disease with dysregulation of the immune system, which usually manifests as erythematous scleroma with hyperplasia of the epidermis. Although the pathogenesis remains unclear, oxidative stress and inflammation are inextricably linked during the development of psoriasis. Therefore, scavenging...

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Cited Boster Product(s): Plus RIPA Lysis Buffer (AR0102-100)

The Deubiquitinase OTUD1 Inhibits Colonic Inflammation by Suppressing RIPK1-Mediated NF-κB Signaling

Authors: Wu, B., Qiang, L., Zhang, Y., Fu, Y., Zhao, M., Lei, Z., Lu, Z., Wei, Y.G...
Journal: Cellular & Molecular Immunology

The E3 ubiquitin ligase (E3)-mediated ubiquitination and deubiquitinase (DUB)-mediated deubiquitination processes are closely associated with the occurrence and development of colonic inflammation. Ovarian tumor deubiquitinase 1 (OTUD1) is involved in immunoregulatory functions linked to infectious diseases. However, the effect of...

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Cited Boster Product(s): Mouse IL-6/Interleukin-6 ELISA Kit PicoKine™ (EK0411); Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine™ (EK0394); Mouse TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine™ (EK0527)

High Throughput Data-Based, Toxicity Pathway-Oriented Development of a Quantitative Adverse Outcome Pathway Network Linking AHR Activation to Lung Damages

Authors: Jin, Y., Qi, G., Shou, Y., Li, D., Liu, Y., Guan, H., Zhang, Q., Chen, S...
Journal: Journal of Hazardous Materials

The quantitative adverse outcome pathway (qAOP) is proposed to inform dose-responses at multiple biological levels for the purpose of toxicity prediction. So far, qAOP models concerning human health are scarce. Previously, we proposed 5 key molecular pathways that led aryl hydrogen receptor (AHR) activation to lung damages. The...

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Cited Boster Product(s): Human IL-6/Interleukin-6 ELISA Kit PicoKine™ (EK0410)

A Novel Biomimetic Nanomedicine System with Anti-Inflammatory and Anti-Osteoporosis Effects Improves the Therapy Efficacy of Steroid-Resistant Nephrotic Syndrome

Authors: Li, J., Zhao, M., Xiang, X., He, Q., Gui, R.
Journal: Journal of Nanobiotechnology

Clinically, steroid-resistant nephrotic syndrome (SRNS) is always prolonged and difficult to treat and easily develops into end-stage renal disease, resulting in a low survival rate. Strategies to reverse steroid resistance and reduce the long-term use of high doses of steroid medicines are urgently needed. In this study, a novel...

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Cited Boster Product(s): Goat Anti-Mouse IgG (H+L) Secondary Antibody, FITC Conjugated (BA1101); Goat Anti-Rabbit IgG (H+L) Secondary Antibody, Cy3 Conjugated (BA1032)

Bioinspired, Injectable, Tissue-Adhesive and Antibacterial Hydrogel for Multiple Tissue Regeneration by Minimally Invasive Therapy

Authors: Zhou, F., Yang, Y., Zhang, W., Liu, S., Shaikh, A.B., Yang, L., Lai, Y...
Journal: Applied Materials Today

Hemorrhage and wound infection after soft tissue trauma are the main factors causing casualties in surgical procedures and disasters. Currently available tissue adhesives for hemorrhage and wound infection treatment remain unsatisfactory due to the lack of ideal adhesive hydrogels that can integrate injectability, tunable mechanical...

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Cited Boster Product(s): Mouse EGF ELISA Kit PicoKine™ (EK0326)

Growth Differentiation Factor 11 Accelerates Liver Senescence Through the Inhibition of Autophagy

Authors: Sun, J., Li, Y., Yang, X., Dong, W., Yang, J., Hu, Q., Zhang, C...
Journal: Aging Cell

The “rejuvenating” effect of growth differentiation factor 11 (GDF11) is called into question recently, and its role, as well as plausible signaling mechanisms in liver senescence, is unclear. To overexpress or knockdown GDF11, aged male mice are injected with a single dose of adeno-associated viruses-GDF11 or adenovirus-small...

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Cited Boster Product(s): RIPA Lysis Buffer (AR0105-100)