Research Spotlight – February 2022

In this month’s Research Spotlight, we highlight a range of our customers’ publications that investigate complex challenges and the development of life-changing innovations to improve patient health.

In this month’s Research Spotlight, we highlight a range of our customers’ publications that investigate complex challenges and the development of life-changing innovations to improve patient health.

Find out how tNIR light treatment might serve as a noninvasive therapeutic alternative for regulating neuronal functions via the improvement of mitochondrial dysfunction mediated by the SIRT1/PGC-1α pathway. In addition, as more studies reveal the key role of circRNAs in cancer, researchers dive deeper into the molecular mechanism of circRNAs in prostate cancer progression.

In the fields of biomedicine and nanotechnology, scientists also successfully develop melanin@mSiO2 and HRPS biomimetic nanoparticles that function as high targeting delivery systems for tumor immunotherapy and RA therapy, respectively.

Scroll down to learn more about the various discoveries and their applications.

Transcranial photobiomodulation therapy ameliorates perioperative neurocognitive disorder through modulation of mitochondrial function in aged mice

Authors: Zhang, X., Wu, W., Luo, Y., Wang, Z.
Journal: Neuroscience

Perioperative neurocognitive disorder (PND) is a serious nervous system complication characterized by progressive cognitive impairment, especially in geriatric population. However, the neuropathogenesis of PND is complex, and there are no approved disease-modifying therapeutic options. Mitochondrial dysfunction has been demonstrated…

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Cited Boster Product(s): Anti-SIRT1 Antibody Picoband™ (A00018-1)

MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα

Authors: Feng, L., Li, C., Zeng, L.W., Gao, D., Sun, Y.H., Zhong, L., Lin, H…
Journal: Signal Transduction and Targeted Therapy

Interleukin-3 (IL-3) is a hematopoietic growth factor and critical regulator of inflammatory response such as sepsis. IL-3 binds to IL-3 receptor α (IL-3Rα), which is then associated with IL-3Rβ to initiate signaling. How IL-3-triggered physiological and pathological effects are regulated at the receptor level is unclear. Here, we...

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Cited Boster Product(s): Mouse IL-1 Beta ELISA Kit PicoKine® (EK0394)

Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p

Authors: Yu, Y.Z., Lv, D.J., Wang, C., Song, X.L., Xie, T., Wang, T., Li, Z.M…
Journal: Molecular Cancer

Background: More and more studies have shown that circular RNAs (circRNAs) play a critical regulatory role in many cancers. However, the potential molecular mechanism of circRNAs in prostate cancer (PCa) remains largely unknown. Methods: Differentially expressed circRNAs were identified by RNA sequencing. The expression of hsa_circ...

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Cited Boster Product(s): 4% Paraformaldehyde (PFA) Solution In PBS (AR1068)

Biomimetic Hybrid Membrane-Coated Xuetongsu Assisted with Laser Irradiation for Efficient Rheumatoid Arthritis Therapy

Authors: Yu, H., Fan, J., Shehla, N., Qiu, Y., Lin, Y., Wang, Z., Cao, L., Li, B…
Journal: ACS Nano

Rheumatoid arthritis (RA) is a systemic autoimmune disease underlying a cascade of chronic inflammatory processes. Over the past decades, the response rate of effective RA treatments has remained scarce despite numerous advancements in the current therapeutic interventions, owing largely to the associated off-target adverse events…

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Cited Boster Product(s): Rat TNF Alpha ELISA Kit PicoKine® (EK0526); Rat IL-1 Beta ELISA Kit PicoKine® (EK0393); Rat IL-6 ELISA Kit PicoKine® (EK0412); Rat IL-10 ELISA Kit PicoKine® (EK0418)

WTAP-mediated m6A modification of lncRNA DIAPH1-AS1 enhances its stability to facilitate nasopharyngeal carcinoma growth and metastasis

Authors: Li, Z.X., Zheng, Z.Q., Yang, P.Y., Lin, L., Zhou, G.Q., Lv, J.W…
Journal: Cell Death & Differentiation

As the most predominant RNA epigenetic regulation in eukaryotic cells, N6-methyladenosine (m6A) plays a critical role in human tumorigenesis and cancer progression. However, the biological function and molecular mechanism of m6A regulation in naso-pharyngeal carcinoma (NPC) remain elusive. Here, we showed that Wilms’ tumor 1-associating…

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Cited Boster Product(s): ISH Detection Kit (POD) (MK1030)

Mitochondrial Targeted Melanin@mSiO2 Yolk-shell Nanostructures for NIR-Ⅱ-driven Photo-Thermal-Dynamic/Immunotherapy

Authors: Zhang, Y., Wang, Q., Ji, Y., Fan, L., Ding, B., Lin, J., Wang, L.
Journal: Chemical Engineering Journal

The challenge of photothermal therapy (PTT) clinical transformation is the limited penetration depth of laser light and the general concern of using synthetic photothermal nanomaterials. Hence, it is of great significance to develop combined cancer therapies based on NIR-II photothermal agents from natural materials. Herein, natural…

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Cited Boster Product(s): Mouse TNF Alpha ELISA Kit PicoKine® (EK0527); Mouse IFN Gamma ELISA Kit PicoKine® (EK0375); Anti-CD8 Alpha Antibody Picoband™ (A02236-1)

Human pluripotent stem cell-derived ectomesenchymal stromal cells promote more robust functional recovery than umbilical cord-derived mesenchymal stromal cells after hypoxic-ischaemic brain damage

Authors: Huang, J., U, K.P., Yang, F., Ji, Z., Lin, J., Weng, Z., Tsang, L.L…
Journal: Theranostics

Aims: Hypoxic-ischaemic encephalopathy (HIE) is one of the most serious complications in neonates and infants. Mesenchymal stromal cell (MSC)-based therapy is emerging as a promising treatment avenue for HIE. However, despite its enormous potential, the clinical application of MSCs is limited by cell heterogeneity, low isolation…

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Cited Boster Product(s): Human NGF Beta ELISA Kit PicoKine® (EK0469); Human TGF-Beta 2 ELISA Kit PicoKine™ (EK0981); Human PDGF-AA ELISA Kit PicoKine™ (EK1696); Human Rantes ELISA Kit PicoKine™ (EK0494)

Prevotellaceae produces butyrate to alleviate PD-1/PD-L1 inhibitor-related cardiotoxicity via PPARα-CYP4X1 axis in colonic macrophages

Authors: Chen, Y., Liu, Y., Wang, Y., Chen, X., Wang, C., Chen, X., Yuan, X…
Journal: Journal of Experimental & Clinical Cancer Research

Background: Immune checkpoint inhibitor-related cardiotoxicity is one of the most lethal adverse effects, and thus, the identification of underlying mechanisms for developing strategies to overcome it has clinical importance. This study aimed to investigate whether microbiota-host interactions contribute to PD-1/PD-L1 inhibitor-related…

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Cited Boster Product(s): Anti-Occludin/OCLN Antibody Picoband™ (A01246-2)

Protective effects and mechanisms of psoralidin against adriamycin-induced cardiotoxicity

Authors: Liang, Z., Chen, Y., Wang, Z., Wu, X., Deng, C., Wang, C., Yang, W…
Journal: Journal of Advanced Research

Introduction: Adriamycin (ADR) is an efficient and common broad-spectrum anticancer drug. However, the cumulative and dose-dependent toxicity induced by ADR severely limits its application in the clinic. Previous studies found that psoralidin (PSO) exhibits remarkable therapeutic effects against multiple cancers. Objectives: The aim…

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Cited Boster Product(s): HRP Conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) (BA1054)

Recurrent moderate hypoglycemia accelerates the progression of Alzheimer's disease through impairment of TRPC6/GLUT3 pathway

Authors: He, C., Li, Q., Cui, Y., Gao, P., Shu, W., Zhou, Q., Wang, L., Li, L…
Journal: JCI Insight

Currently, the most effective strategy for dealing with Alzheimer’s disease (AD) is delaying the onset of dementia. Severe hypoglycemia is strongly associated with dementia; however, the effects of recurrent moderate hypoglycemia (RH) on progression of cognitive deficits in diabetic patients with genetic susceptibility to AD remain…

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Cited Boster Product(s): Mouse IL-6 ELISA Kit PicoKine® (EK0411); Mouse IL-1 Beta ELISA Kit PicoKine® (EK0394); Mouse IFN Gamma ELISA Kit PicoKine® (EK0375); Mouse TNF Alpha ELISA Kit PicoKine® (EK0527)