Research Spotlight - February 2021

The February edition of Research Spotlight provides 10 recent research discoveries from scientists whom Boster has served, which include new insights on the interactions between nanoparticles and human health as well as the underlying mechanisms.

The pathology-improvement effects of siRNA-based drugs on lung disorders, trichostatin A on Alzheimer’s disease, and propofol on microglial phagocytosis were also explored.

Scroll down to find out more about each featured publication.

Combined Exposure of Alumina Nanoparticles and Chronic Stress Exacerbates Hippocampal Neuronal Ferroptosis via Activating IFN-γ/ASK1/JNK Signaling Pathway in Rats

Authors: Zhang, H., Jiao, W., Cui, H., Sun, Q., & Fan, H.
Journal : Journal of Hazardous Materials

Alumina nanoparticles (AlNPs) exposure causes hippocampal-dependent cognitive dysfunction. However, whether chronic stress exacerbates AlNPs-induced hippocampal lesion and its mechanism remains unclear. This study was aimed to investigate the combined effects and mechanisms of AlNPs and chronic stress on the hippocampal lesion. The...

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Cited Boster Product(s): Rat TNF Alpha ELISA Kit PicoKine™ (EK0526); Rat IL-1 Beta ELISA Kit PicoKine™ (EK0393); Rat IL-6 ELISA Kit PicoKine™ (EK0412); Rat IFN Gamma ELISA Kit PicoKine™ (EK0374)

Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-Induced Gastric Ulcer in Wistar Rats: In Silico and In Vivo Studies

Authors: Nabil, M., El Raey, M.A., Abdo, W., Abdelfattah, M.A.O…
Journal: Antioxidants

We have previously reported that the leaf extract of Albizia anthelmintica exhibited substantial antioxidant, anti-inflammatory, analgesic, and antipyretic properties in vivo. We also comprehensively characterized the active phytoconstituents and found several flavonoids and galloyl glucosides derivatives. In the current work...

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Cited Boster Product(s): Broad Spectrum Protease Inhibitor Cocktail (100x) (AR1182); Anti-IKK Beta/IKBKB Antibody (PA2036-1); Anti-Beta Actin ACTB Rabbit Monoclonal Antibody (M01263)

Poly(lactide-co-glycolide) Nanoparticles Mediate Sustained Gene Silencing and Improved Biocompatibility of siRNA Delivery Systems in Mouse Lungs after Pulmonary Administration

Authors: Wu, L., Wu, L.P., Wu, J., Sun, J., He, Z., Rodríguez-Rodríguez, C…
Journal: ACS Applied Materials & Interfaces

Pulmonary delivery of small interfering RNA (siRNA)-based drugs is promising in treating severe lung disorders characterized by the upregulated expression of disease-causing genes. Previous studies have shown that the sustained siRNA release in vitro can be achieved from polymeric matrix nanoparticles based on poly(lactide-co-...

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Cited Boster Product(s): Mouse IL-6 ELISA Kit PicoKine™ (EK0411); Mouse TNF Alpha ELISA Kit PicoKine™ (EK0527); Mouse IL-1 Beta ELISA Kit PicoKine™ (EK0394); Mouse IFN Gamma ELISA Kit PicoKine™ (EK0375); Mouse IL-4 ELISA Kit PicoKine™ (EK0405)

linc-AAM Facilitates Gene Expression Contributing to Macrophage Activation and Adaptive Immune Responses

Authors: Chen, X., He, Y., Zhu, Y., Du, J., & Sun, H.
Journal: Cell Reports

Although various long noncoding RNAs (lncRNAs) are specifically expressed in activated macrophages, their in vivo functions and mechanisms of action are largely unexplored. Here, we identify a long intergenic noncoding RNA associated with activated macrophage (linc-AAM) and elucidate its function and mechanisms. linc-AAM is highly...

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Cited Boster Product(s): Mouse IL-10 ELISA Kit PicoKine™ (EK0417); Mouse TNF Alpha ELISA Kit PicoKine™ (EK0527); Mouse IL-1 Beta ELISA Kit PicoKine™ (EK0394); Mouse MCP-1 ELISA Kit PicoKine™ (EK0568); Mouse IL-6 ELISA Kit PicoKine™ (EK0411)

Trichostatin A Ameliorates Alzheimer’s Disease-Related Pathology and Cognitive Deficits by Increasing Albumin Expression and Aβ Clearance in APP/PS1 Mice

Authors: Su, Q., Li, T., He, P.F., Lu, X.C., Yu, Q., Gao, Q.C., Wang, Z.J…
Journal: Alzheimer's Research & Therapy

Background: Alzheimer’s disease (AD) is an intractable neurodegenerative disorder in the elderly population, currently lacking a cure. Trichostatin A (TSA), a histone deacetylase inhibitor, showed some neuroprotective roles, but its pathology-improvement effects in AD are still uncertain, and the underlying mechanisms remain to be...

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Cited Boster Product(s): HRP Conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) (BA1054); HRP Conjugated AffiniPure Goat Anti-Mouse IgG (H+L) (BA1050); Goat Anti-Mouse IgG (H+L) Secondary Antibody, Cy3 Conjugated (BA1031); Goat Anti-Rabbit IgG (H+L) Secondary Antibody, Cy3 Conjugated (BA1032); Plus RIPA Lysis Buffer (AR0102-100); Broad Spectrum Phosphatase Inhibitor Cocktail (AR1183); SDS-PAGE Protein Loading Buffer 2X (Reducing) (AR0131-20); SDS-PAGE Gel Preparation Kit (AR0138)

SIRT1-Induced Deacetylation of Akt Expedites Platelet Phagocytosis and Delays Human Endometrial Microvascular Endothelial Cell Aging

Authors: Lan, Y., Dong, M., Li, Y., Diao, Y., Chen, Z., & Li, Y.
Journal: Molecular Therapy: Nucleic Acid

Maintaining the health of endothelium is of critical importance to the prevention against cell aging. The current study was performed to clarify the role of SIRT1 on platelet phagocytosis in cell aging and identified its downstream molecular mechanism. Platelet phagocytosis by human endometrial microvascular endothelial cells...

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Cited Boster Product(s): RIPA Lysis Buffer (AR0105-100); BCA Protein Assay Kit (AR0146)

Role of Sciellin in Gallbladder Cancer Proliferation and Formation of Neutrophil Extracellular Traps

Authors: Li, Y., Yuan, R., Ren, T., Yang, B., Miao, H., Liu, L., Li, Y., Cai, C…
Journal: Cell Death & Disease

Apart from primary tumor development and metastasis, cancer-associated thrombosis is the second cause of cancer death in solid tumor malignancy. However, the mechanistic insight into the development of gallbladder cancer (GBC) and cancer-associated thrombosis remains unclear. This study aimed to investigate the mechanistic role of...

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Cited Boster Product(s): Human IL-8 ELISA Kit PicoKine™ (EK0413)

Propofol Suppresses Microglial Phagocytosis Through the Downregulation of MFG-E8

Authors: Cai, X., Li, Y., Zheng, X., Hu, R., Li, Y., Xiao, L., & Wang, Z.
Journal: Journal of Neuroinflammation

Background: Microglia are highly motile phagocytic cells in the healthy brain with surveillance and clearance functions. Although microglia have been shown to engulf cellular debris following brain insult, less is known about their phagocytic function in the absence of injury. Propofol can inhibit microglial activity, including...

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Cited Boster Product(s): Mouse MFGE8 / Lactadherin / Milk Fat Globule 1 ELISA Kit PicoKine™ (EK1194)

Novel Nonsecosteroidal Vitamin D Receptor Modulator Combined with Gemcitabine Enhances Pancreatic Cancer Therapy through Remodeling of the Tumor Microenvironment

Authors: Kang, Z., Wang, C., Tong, Y., Li, Y., Gao, Y., Hou, S., Hao, M…
Journal: Journal of Medicinal Chemistry

In a pancreatic tumor microenvironment, activated pancreatic stellate cells (PSCs) produce extracellular matrix (ECM) to form a barrier to drug penetration. Moreover, the interaction between cancer cells and activated PSCs promotes the tumor growth. Vitamin D receptor (VDR), as a key regulator to promote the recovery of PSCs to the...

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Cited Boster Product(s): HRP Conjugated Goat Anti-Mouse/Rabbit IgG SABC Kit (SA1020)

Human Foreskin-Derived Dermal Stem/Progenitor Cell-Conditioned Medium Combined with Hyaluronic Acid Promotes Extracellular Matrix Regeneration in Diabetic Wounds

Authors: Xin, Y., Xu, P., Wang, X., Chen, Y., Zhang, Z., & Zhang, Y.
Journal: Stem Cell Research & Therapy

Background: Diabetic wounds remain a challenging clinical problem, which requires further treatment development. Published data showed that dermis-derived stem/progenitor cells (DSPCs) display superior wound healing in vitro. The beneficial effects of DSPCs are mediated through paracrine secretion, which can be obtained from...

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Cited Boster Product(s): DAPI For Nucleic Acid Staining (AR1176 AR1177)