Research Spotlight – February 2020

At Bosterbio, our customers’ research is our priority. Our mission is to help customers achieve their research goals so that they can stay on the cutting edge of research.

This February, we’d like to feature a selected number of recently published research from the scientists whom Boster has served.

Scroll down to see 10 research discoveries from different fields.

Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury microenvironment

Authors: Zeng, H., Liu, N., Yang, Y., Xing, H., Liu, X., Li, F., La, G., Huang, M...
Journal: Journal of Neuroinflammation

Background: The prognosis of spinal cord injury (SCI) is closely related to secondary injury, which is dominated by neuroinflammation. There is evidence that α-synuclein aggregates after SCI and that inhibition of α-synuclein aggregation can improve the survival of neurons after SCI, but the mechanism is still unclear. This study was...

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Cited Boster Product(s): Citrate Buffer Powder (AR0024); Goat Anti-Rabbit IgG (H+L) Secondary Antibody, Cy3 Conjugate (BA1032); Rat TNF Alpha ELISA Kit PicoKine™ (EK0526); Rat IL-1 Beta ELISA Kit PicoKine™ (EK0393); Rat IL-2 ELISA Kit PicoKine™ (EK0399); Rat IL-10 ELISA Kit PicoKine™ (EK0418); Rat IL-4 ELISA Kit PicoKine™ (EK0406); Rat TGF Beta 1 ELISA Kit PicoKine™ (EK0514)

Differential Expression of Nicotine Acetylcholine Receptors Associates with Human Breast Cancer and Mediates Antitumor Activity of αO-Conotoxin GeXIVA

Authors: Sun, Z., Zhangsun, M., Dong, S., Liu, Y., Qian, J., Zhangsun, D., & Luo, S.
Journal: Marine Drugs

Nicotinic acetylcholine receptors (nAChRs) are membrane receptors and play a major role in tumorigenesis and cancer progression. Here, we have investigated the differential expression of nAChR subunits in human breast cancer cell lines and breast epithelial cell lines at mRNA and protein levels and the effects of the αO-...

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Cited Boster Product(s): Anti-Nicotinic Acetylcholine Receptor alpha 5/CHRNA5 Antibody Picoband™ (A02359-2)

Environmental arginine controls multinuclear giant cell metabolism and formation

Authors: Brunner, J.S., Vulliard, L., Hofmann, M., Kieler, M., Lercher, A., Vogel, A...
Journal: Nature Communications

Multinucleated giant cells (MGCs) are implicated in many diseases including schistosomiasis, sarcoidosis and arthritis. MGC generation is energy intensive to enforce membrane fusion and cytoplasmic expansion. Using receptor activator of nuclear factor kappa-Β ligand (RANKL) induced osteoclastogenesis to model MGC formation,...

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Cited Boster Product(s): Mouse TNFSF11/RANKL ELISA Kit PicoKine™ (EK0843)

Ligand-installed anti-VEGF genomic nanocarriers for effective gene therapy of primary and metastatic tumors

Authors: Zhang, H., Liu, J., Chen, Q., & Mi, P.
Journal: Journal of Controlled Release

The systemic dosage regimen exhibited low therapeutic efficacy and incurred severe adverse effects, thus, the development of tumor-targeted therapeutics is crucially important for tumor precision therapy. Herein, the active targeted modulation of tumor microenvironments was schemed by developing hyaluronic acid-installed...

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Cited Boster Product(s): Mouse FLT1/VEGFR1 ELISA Kit PicoKine™ (EK0589)

Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation

Authors: Shen, L., Kang, L., Wang, D., Xun, J., Chen, C., Du, L., Zhang, M., Gong, J...
Journal: Cancer Letters

Macrophages serve as the first line of communication between tumors and the rest of the immune system, and understanding the interplay between macrophage and tumor cells is essential for developing novel macrophage-based strategy against tumor. Here, we show that deletion of legumain in macrophages activates senescence of...

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Cited Boster Product(s): Mouse IL-1 Beta ELISA Kit PicoKine™ (EK0394)

USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA

Authors: Zhang, H.Y., Liao, B.W., Xu, Z.S., Ran, Y., Wang, D.P., Yang, Y., Luo, W.W...
Journal: PLOS Pathogens

Mediator of IRF3 activation (MITA, also known as stimulator of interferon genes, STING) senses the second messenger cyclic GMP-AMP (cGAMP) which is synthesized upon DNA virus infection and activates innate antiviral immune response. It has been demonstrated that the activity of MITA is delicately regulated by various post-translational...

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Cited Boster Product(s): Mouse CXCL10/IP-10 ELISA Kit PicoKine™ (EK0736)

SorCS2 facilitates release of endostatin from astrocytes and controls post‐stroke angiogenesis

Authors: Malik, A.R., Lips, J., Gorniak-Walas, M., Broekaart, D.W.M., Asaro, A...
Journal: GLIA

SorCS2 is an intracellular sorting receptor of the VPS10P domain receptor gene family recently implicated in oxidative stress response. Here, we interrogated the relevance of stress‐related activities of SorCS2 in the brain by exploring its role in ischemic stroke in mouse models and in patients. Although primarily seen in neurons in the healthy...

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Cited Boster Product(s): Mouse Endostatin ELISA Kit PicoKine™ (EK1376)

Methylglyoxal-Dependent Glycative Stress and Deregulation of SIRT1 Functional Network in the Ovary of PCOS Mice

Authors: Di Emidio, G., Placidi, M., Rea, F., Rossi, G., Falone, S., Cristiano, L...
Journal: Cells

Advanced glycation end-products (AGEs) are involved in the pathogenesis and consequences of polycystic ovary syndrome (PCOS), a complex metabolic disorder associated with female infertility. The most powerful AGE precursor is methylglyoxal (MG), a byproduct of glycolysis, that is detoxified by the glyoxalase system. By using a...

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Cited Boster Product(s): Goat Anti-Rabbit IgG (H+L) Secondary Antibody, HRP Conjugate (BA1054)

Long-term probiotic intervention mitigates memory dysfunction through a novel H3K27me3-based mechanism in lead-exposed rats

Authors: Xiao, J., Wang, T., Xu, Y., Gu, X., Li, D., Niu, K., Wang, T., Zhao, J...
Journal: Translational Psychiatry

Chronic lead exposure is associated with the development of neurodegenerative diseases, characterized by the long-term memory decline. However, whether this pathogenesis could be prevented through adjusting gut microbiota is not yet understood. To address the issue, pregnant rats and their female offspring were treated with lead (125 ppm) or separately the...

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Cited Boster Product(s): Goat Anti-Rabbit IgG (H+L) Secondary Antibody, Unconjugated (BA1039)

Evidence for the Presence of Long-Lived Plasma Cells in Nasal Polyps

Authors: Zhang, Y.N., Song, J., Zhai, G.T., Wang, H., Luo, R.Z., Li, J.X., Liao, B...
Journal: Allergy, Asthma & Immunology Research

Purpose: Plasma cells and immunoglobulins (Igs) play a pivotal role in the induction and maintenance of chronic inflammation in nasal polyps. During secondary immune responses, plasma cell survival and Ig production are regulated by the local environment. The purpose of the present study was to investigate the...

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Cited Boster Product(s): 3% Hydrogen Peroxide (H2O2) Solution, Lab Grade (AR1108); Normal Rabbit Serum (Blocking Solution) (AR1010)