Research Spotlight – February 2019

Our February edition of Research Spotlight features 10 recent research discoveries from scientists whom Boster has served.

This month’s selected research publications investigate targets related to a number of cancers, such as osteosarcoma, hepatocellular carcinoma, pancreatic carcinoma, and glioblastoma, and also include studies that examine targets of Parkinson’s disease and type 2 diabetes mellitus.

Scroll down to learn more about these new scientific discoveries.

The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment

Authors: De Marchi, E., Orioli, E., Pegoraro, A., Sangaletti, S., Portararo, P...
Journal: Oncogene

In the tumor microenvironment (TME) ATP and its receptor P2X7 exert a pivotal influence on cancer growth and tumor–host interactions. Here we analyzed the different effect of P2X7 genetic deficiency versus its antagonism on response against P2X7...

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Cited Boster Product(s): Mouse TGF Beta 1 PicoKine™ ELISA Kit (EK0515); Mouse IL-1 Beta PicoKine™ ELISA Kit (EK0394); Mouse TNF Alpha PicoKine™ ELISA Kit (EK0527)

Toll-like receptor 2 and Toll-like receptor 4 exhibit distinct regulation of cancer cell stemness mediated by cell death-induced high-mobility group box 1

Authors: Chen, X., Cheng, F., Liu, Y., Zhang, L., Song, L., Cai, X., You, T...
Journal: EBioMedicine

Background: High-mobility group box 1 (HMGB1), a common extracellular damage associated molecular pattern molecule, is overexpressed in several solid tumors including pancreatic carcinoma. We previously observed that radiotherapy...

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Cited Boster Product(s): Goat Anti-Rabbit IgG (H+L) Secondary Antibody, Cy3 Conjugate (BA1032); DAPI for nucleic acid staining (AR1176)

5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress

Authors: Xu, L.L., Wu, Y.F., Yan, F., Li, C.C., Dai, Z., You, Q.D., Jiang, Z.Y., & Di…
Journal: Free Radical Biology and Medicine

Parkinson's disease (PD) is the second most common aging-related neurodegenerative disease worldwide. Oxidative stress and neuroinflammation are critical events in the degeneration of dopaminergic neurons in PD. In this study, we found that DDO-7263, a...

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Cited Boster Product(s): Mouse IL-1 Beta PicoKine™ ELISA Kit (EK0394); Mouse TNF Alpha PicoKine™ ELISA Kit (EK0527)

IGFBP5 suppresses oleate‐induced intramyocellular lipids deposition and enhances insulin signaling

Authors: Xiang, A., Chu, G., Zhu, Y., Ma, G., Yang, G., & Sun, S.
Journal: Journal of Cellular Physiology

Excess intramyocellular lipids are often accompanied by muscle insulin resistance (IR) and type 2 diabetes. The mechanism of the formation of intramyocellular lipids is unclear yet. In this study, we optimized the cellular model of intramyocellular lipids from...

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Cited Boster Product(s): Goat Anti-Rabbit IgG (H+L) Secondary Antibody, HRP Conjugate (BA1054); Goat Anti-Mouse IgG (H+L) Secondary Antibody, HRP Conjugate (BA1050)

VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages

Authors: Huang, X., Feng, Z, Jiang, Y., Li, J., Xiang, Q., Guo, S., Yang, C., Fei, L...
Journal: Science Advances

Hyperactivation of the NLRP3 inflammasome contributes to the pathogenesis of multiple diseases, but the mechanisms underlying transcriptional regulation of Nlrp3 remain elusive. We demonstrate here that macrophages lacking V-set and...

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Cited Boster Product(s): Mouse IL-1 Beta PicoKine™ ELISA Kit (EK0394)

TBL1XR1 promotes migration and invasion in osteosarcoma cells and is negatively regulated by miR-186-5p

Authors: Cao, Q., Wang, Z., Wang, Y., Liu, F., Dong, Y., Zhang, W., Wang, L...
Journal: American Journal of Cancer Research

TBL1XR1 has been reported to play promoting roles in various malignances, yet little is known about its role in osteosarcoma, and the up-stream molecules regulating TBL1XR1 are also unclear. In the present study, we investigated the clinical...

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Cited Boster Product(s): Cell Counting Kit-8 (CCK-8) (AR1160)

Evaluation of Activated Leucocyte Cell Adhesion Molecule in Hepatocellular Carcinoma Patients

Authors: Samuel, E., Shehata, A.S., Wahab, M.A., & Abdel-Aziz, A.F.
Journal: World Journal of Pharmacy and Pharmaceutical Sciences

Background: Besides, cost/effectiveness and efficacy of surveillance and screening of patients with cirrhotic liver for the diagnosis of hepatocellular carcinoma (HCC) is still debated. Search for suitable biomarkers of HCC is very intense. Roles of activated...

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Cited Boster Product(s): Human ALCAM/Cd166 PicoKine™ ELISA Kit (EK0995)

Repression of long non-coding RNA MEG3 restores nerve growth and alleviates neurological impairment after cerebral ischemia-reperfusion injury in a rat model

Authors: You, D., & You, H.
Journal: Biomedicine & Pharmacotherapy

Objective: This study was performed to investigate effect of long non-coding RNA (lncRNA) MEG3 on nerve growth and neurological impairment in a rat model after cerebral ischemia-reperfusion injury (IRI) through the Wnt/β-catenin signaling...

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Cited Boster Product(s): BCA Protein Assay Kit (AR0146)

FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation

Authors: Yan, J., Zhao, Q., Gabrusiewicz, K., Kong, L.Y., Xia, X., Wang, J...
Journal: Nature Communications

Few studies implicate immunoregulatory gene expression in tumor cells in arbitrating brain tumor progression. Here we show that fibrinogen-like protein 2 (FGL2) is highly expressed in glioma stem cells and primary glioblastoma (GBM) cells. FGL2 knockout...

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Cited Boster Product(s): Mouse Flt-3 Ligand PicoKine™ ELISA Kit (EK0355)

MicroRNA-125b-5p improves pancreatic β-cell function through inhibiting JNK signaling pathway by targeting DACT1 in mice with type 2 diabetes mellitus

Authors: Yu, C.Y., Yang, C.Y., & Rui, Z.L.
Journal: Life Sciences

Type 2 diabetes mellitus (T2DM) is a progressive disease, accompanied by increased insulin resistance and deteriorating β-cell function. Previous studies have revealed that microRNA (miRNA) plays a crucial role in the treatment...

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Cited Boster Product(s): SDS-PAGE Gel Preparation Kit (AR0138)