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Research Spotlight - December 2022
Christmas is fast approaching and we’re delighted to present this year’s last issue of Research Spotlight, which features 10 selected publications from scientists whom Boster has served.
Recently, increasing attention has been focused on nanomaterials for therapeutic applications. Researchers demonstrated the immunomodulatory and spatiotemporal drug release effects of nanohydroxyapatite complexes, MSC-derived extracellular vesicles, antioxidant-constructed nanodrugs, Sr/Cu-borosilicate glass nanoparticles, and Mg-incorporated microspheres for cancer and cell injury.
Among the studies, scientists also highlighted the promising results of peptide- and adipose-tissue functionalized hydrogels for wound healing and tissue regeneration.
Scroll down to learn more about these discoveries!
Nanohydroxyapatite Stimulates PD-L1 Expression to Boost Melanoma Combination Immunotherapy
Authors: Yang, Y., Cui, Y., Cao, W., Zhao, M., Lin, W., Xu, R., Xu, Y., Chen, Y…
Journal: ACS Nano
Although checkpoint-inhibitor immunotherapy held tremendous advances, improving immune response during treatment has always been an urgent clinical issue. With the help of mRNA microarray technology, it was found that short rod-like nanohydroxyapatite (nHA) promoted the upregulation of CD274 and PD-L1 related gene transcription, which...
Cited Boster Product(s): Anti-GPNMB/Gpnmb Picoband™ Antibody (A02439-1)
Hair Follicle-MSC-Derived Small Extracellular Vesicles as a Novel Remedy for Acute Pancreatitis
Authors: Li, S., Li, H., Zhangdi, H., Xu, R., Zhang, X., Liu, J., Hu, Y., Ning, D…
Journal: Journal of Controlled Release
Background: Hair follicle-derived mesenchymal stem cell (HF-MSC)-based therapies protect against acute pancreatitis (AP). However, accumulating evidence suggests that MSC-based therapy mainly involves the secretion of MSC-derived small extracellular vesicles (MSC-sEVs) through paracrine effects. Thus, the present research investigated...
Cited Boster Product(s): Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine® (EK0394); Mouse IL-18 ELISA Kit PicoKine® (EK0433)
Structures of the CcmABCD heme Release Complex at Multiple States
Authors: Li, J., Zheng, W., Gu, M., Han, L., Luo, Y., Yu, K., Sun, M., Zong, Y…
Journal: Nature Communications
Cytochromes c use heme as a cofactor to carry electrons in respiration and photosynthesis. The cytochrome c maturation system I, consisting of eight membrane proteins (CcmABCDEFGH), results in the attachment of heme to cysteine residues of cytochrome c proteins. Since all c-type cytochromes are periplasmic, heme is first transported...
Cited Boster Product(s): HRP Conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) (BA1054)
Spontaneous Immunomodulation and Regulation of Angiogenesis and Osteogenesis by Sr/Cu-Borosilicate Glass (BSG) Bone Cement to Repair Critical Bone Defects
Authors: Li, S., Zhang, L., Liu, C., Kim, J., Su, K., Chen, T., Zhao, L., Lu, X…
Journal: Bioactive Materials
Injectable bone biomaterials like bone cement should be designed and fabricated with certain biological criteria, which include: 1) recruitment and polarization of the macrophages from M1 (pro-inflammatory) to M2 (anti-inflammatory) phenotype, 2) enhance vascularization, and 3) activate osteogenic differentiation of bone marrow-derived...
Cited Boster Product(s): 4% Paraformaldehyde (PFA) Solution In PBS (AR1068)
Elevated Neutrophil Extracellular Traps by HBV-Mediated S100A9-TLR4/RAGE-ROS Cascade Facilitate the Growth and Metastasis of Hepatocellular Carcinoma
Authors: Zhan, X., Wu, R., Kong, X.H., You, Y., He, K., Sun, X.Y., Huang, Y...
Journal: Cancer Communications
Background: Neutrophil extracellular traps (NETs) are considered significant contributors to cancer progression, especially metastasis. However, it is still unclear whether NETs are involved in hepatitis B virus (HBV)-related hepatocarcinogenesis and have potential clinical significance during evaluation and management...
Cited Boster Product(s): Cell Counting Kit-8 (CCK-8) (AR1160); Goat Anti-Rabbit IgG (H+L) Secondary Antibody, FITC Conjugated (BA1105); DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) For Nucleic Acid Staining (AR1176)
Cancer-Associated Fibroblasts Facilitate Premetastatic Niche Formation Through lncRNA SNHG5-Mediated Angiogenesis and Vascular Permeability in Breast Cancer
Authors: Zeng, H., Hou, Y., Zhou, X., Lang, L., Luo, H., Sun, Y., Wan, X...
Journal: Theranostics
Background: Metastasis is the leading cause of death in patients with breast cancer (BC). Primary tumors create a premetastatic niche (PMN) in secondary organs for subsequent metastases. Cancer-associated fibroblasts (CAFs) are a predominant stromal component in the tumor microenvironment and serve as a major contributor to tumor...
Cited Boster Product(s): RIPA Lysis Buffer (AR0105-100)
Biodegradable Magnesium Incorporated Microspheres Enable immunomodulation and Spatiotemporal Drug Release for the Treatment of Osteonecrosis of the Femoral Head
Authors: Yang, F., Xu, C., Zhang, W., Sun, L., Feng, G., Ning, T., Wang, W...
Journal: Composites Part B: Engineering
Osteonecrosis of the femoral head (ONFH) is a progressive disease that may lead to collapse of the femoral head and subsequently, progression to osteoarthritis of the hip. Although biomaterials have been widely used as carriers of active pharmaceutical ingredient for the treatment of early ONFH, current carriers are incapable...
Cited Boster Product(s): Human BMP-2 ELISA Kit PicoKine® (EK0311)
Pre-Clinical Evaluation of Thermosensitive Decellularized Adipose Tissue/Platelet-Rich Plasma Interpenetrating Polymer Network Hydrogel for Wound Healing
Authors: Tang, J., Li, H., Peng, H., Zhang, Z., Liu, C., Cheng, Y., Wang, K...
Journal: Materials Today Bio
Wound healing remains a challenge worldwide, and an ideal wound dressing that promotes healing is urgently needed. In this study, we developed a thermosensitive injectable hydrogel known as the thermosensitive decellularized adipose tissue/platelet-rich plasma interpenetrating polymer network (t-DPI) hydrogel based on decellularized...
Cited Boster Product(s): Cell Counting Kit-8 (CCK-8) (AR1160); Anti-CD31/Pecam1 Antibody Picoband™ (A01513-3); Goat Anti-Rabbit IgG (H+L) Secondary Antibody, Cy3 Conjugated (BA1032); Goat Anti-Mouse IgG (H+L) Secondary Antibody, FITC Conjugated (BA1101)
Peptide-Functionalized Double Network Hydrogel with Compressible Shape Memory Effect for Intervertebral Disc Regeneration
Authors: Ho, C.Y., Wang, C.C., Wu, T.C., Kuan, C.H., Liu, Y.C., Wang, T.W.
Journal: Bioengineering & Translational Medicine
As a prominent approach to treat intervertebral disc (IVD) degeneration, disc transplantation still falls short to fully reconstruct and restore the function of native IVD. Here, we introduce an IVD scaffold consists of a cellulose-alginate double network hydrogel-based annulus fibrosus (AF) and a cellulose hydrogel-based nucleus...
Cited Boster Product(s): Rat GDF5/Bmp 14 ELISA Kit PicoKine® (EK1504)
Dietary Antioxidant-Constructed Nanodrugs Can High-Efficiently Kill Cancer Cells while Protecting Noncancer Cells
Authors: Liao, C., Wang, X., Zhou, X., Wang, D., Zhang, Z., Liu, Y., Wu, X...
Journal: ACS Applied Materials & Interfaces
Despite great advances, the development of cancer drugs that can efficiently kill cancer cells while protecting noncancer cells has not been achieved. By using only dietary antioxidants vitamin C (VC) and (R)-(+)-lipoic acid (LA), we herein develop a nanodrug VC@cLAV featuring the above function. After entering cells, cLAV dissociates...
Cited Boster Product(s): Human IL-6/Interleukin-6 ELISA Kit PicoKine® (EK0410); Human TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine® (EK0525)
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