Research Spotlight - December 2020

The December edition of Research Spotlight highlights 10 recent research discoveries from scientists whom Boster has served.

In these studies, the effects of several key proteins and their signaling pathways were explored in correlation to the progression and activation of cancer cells, diabetic nephropathy, inflammation, and brain injury.

The role of polysulfides as potential tumor suppressors and regulators might represent an alternative therapeutic candidate for the management of diabetic nephropathy. Additionally, several promising potential therapeutic strategies for enhanced immunotherapy, such as enhanced drug delivery systems, ultrasound-guided platelet-rich plasma injection, and the role of mechanical cues in vascular biology were also investigated.

Scroll down to find more information about these new scientific discoveries.

Polysulfide-Mediated Sulfhydration of SIRT1 Prevents Diabetic Nephropathy by Suppressing Phosphorylation and Acetylation of p65 NF-κB and STAT3

Authors: Sun, H.J., Xiong, S.P., Cao, X., Cao, L., Zhu, M.Y., Wu, Z.Y., & Bian, J.S.
Journal: Redox Biology

Diabetic kidney disease is known as a major cause of chronic kidney disease and end stage renal disease. Polysulfides, a class of chemical agents with a chain of sulfur atoms, are found to confer renal protective effects in acute kidney injury. However, whether a polysulfide donor, sodium tetrasulfide (Na2S4), confers protective...

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Cited Boster Product(s): Mouse TNF Alpha ELISA Kit PicoKine™ (EK0527); Mouse IL-1 Beta ELISA Kit PicoKine™ (EK0394); Mouse VCAM-1 ELISA Kit PicoKine™ (EK0538)

Development of Thermosensitive Resiquimod-Loaded Liposomes for Enhanced Cancer Immunotherapy

Authors: Zhang, H., Tang, W.L., Kheirolomoom, A., Fite, B.Z., Wu, B., Lau, K...
Journal: Journal of Controlled Release

Resiquimod (R848) is a toll-like receptor 7 and 8 (TLR7/8) agonist with potent antitumor and immunostimulatory activity. However, systemic delivery of R848 is poorly tolerated because of its poor solubility in water and systemic immune activation. In order to address these limitations, we developed an intravenously-injectable...

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Cited Boster Product(s): Anti-Macrosialin CD68 Antibody (PA1518)

KPNB1-Mediated Nuclear Translocation of PD-L1 Promotes Non-Small Cell Lung Cancer Cell Proliferation via the Gas6/MerTK Signaling Pathway

Authors: Du, W., Zhu, J., Zeng, Y., Liu, T., Zhang, Y., Cai, T., Fu, Y., Zhang, W...
Journal: Cell Death & Differentiation

In addition to the role of programmed cell death ligand 1 (PD-L1) in facilitating tumour cells escape from immune surveillance, it is considered as a crucial effector in transducing intrinsic signals to promote tumour development. Our previous study has pointed out that PD-L1 promotes non-small cell lung cancer (NSCLC) cell...

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Cited Boster Product(s): Cell Counting Kit-8 (CCK-8) (AR1160)

Ultrasound-Guided Platelet-Rich Plasma Injection and Multimodality Ultrasound Examination of Peripheral Nerve Crush Injury

Authors: Zhu, Y., Jin, Z., Wang, J., Chen, S., Hu, Y., Ren, L., Wang, Y., Song, Q...
Journal: npj Regenerative Medicine

Ultrasound-guided platelet-rich plasma (PRP) injection is able to make up for the limitations of applying a single growth factor. The goal of this study was to investigate the effects of serial ultrasound-guided PRP injections of the appropriate concentration on the treatment of sciatic nerve crush injury, and explore the value...

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Cited Boster Product(s): Rat NGF/NGF Beta ELISA Kit PicoKine™ (EK0471); Rat VEGF ELISA Kit PicoKine™ (EK0540); Rat GDNF ELISA Kit PicoKine™ (EK0363)

Long Noncoding RNA CASC11 Promotes Hepatocarcinogenesis and HCC Progression Through EIF4A3‐Mediated E2F1 Activation

Authors: Song, H., Liu, Y., Li, X., Chen, S., Xie, R., Chen, D., Gao, H., Wang, G...
Journal: Clinical and Translational Medicine

Background: Growing evidences have been revealing that long noncoding RNAs are vital factors in oncogenesis and tumor development. Among them, cancer susceptibility candidate 11 (CASC11) has displayed an impressively essential role in various kinds of cancers including hepatocellular carcinoma (HCC). Nevertheless, its role and...

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Cited Boster Product(s): ISH Detection Kit (POD) (MK1030)

A Novel SIRT6 Activator Ameliorates Neuroinflammation and Ischemic Brain Injury via EZH2/FOXC1 Axis

Authors: He, T., Shang, J., Gao, C., Guan, X., Chen, Y., Zhu, L., Zhang, L...
Journal: Acta Pharmaceutica Sinica B

Ischemic stroke is the second leading cause of death worldwide with limited medications and neuroinflammation was recognized as a critical player in the progression of stroke, but how to control the overactive neuroinflammation is still a long-standing challenge. Here, we designed a novel SIRT6 activator MDL-811 which remarkably...

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Cited Boster Product(s): Mouse TNF Alpha ELISA Kit PicoKine™ (EK0527)

Stretchable Electrode Based on Au@Pt Nanotube Networks for Real-Time Monitoring of ROS Signaling in Endothelial Mechanotransduction

Authors: Fan, W.T., Qin, Y., Hu, X.B., Yan, J., Wu, W.T., Liu, Y.L., & Huang, W.H.
Journal: Analytical Chemistry

Vascular endothelial cells (ECs) are natively exposed to dynamic cyclic stretch and respond to it by the production of vasoactive molecules. Among them, reactive oxygen species (ROS) are closely implicated to the endothelial function and vascular homeostasis. However, the dynamic monitoring of ROS release during endothelial...

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Cited Boster Product(s): Goat Anti-Rabbit IgG (H+L) Secondary Antibody, DyLight®488 Conjugated (BA1127)

MicroRNA-200b/c-3p Regulate Epithelial Plasticity and Inhibit Cutaneous Wound Healing by Modulating TGF-β-Mediated RAC1 Signaling

Authors: Tang, H., Wang, X., Zhang, M., Yan, Y., Huang, S., Ji, J., Xu, J., Zhang, Y...
Journal: Cell Death & Disease

Cutaneous wound healing is pivotal for human skin to regain barrier function against pathogens. MicroRNAs (miRNAs) have been found to play regulatory roles in wound healing. However, the mechanism of miRNA regulation remains largely unknown. In this study, we focused on microRNA-200b/c-3p (miR-200b/c-3p) whose expression was...

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Cited Boster Product(s): Cy3 Conjugated Goat Anti-Mouse IgG SABC Kit (SA1072)

Efficacy of a Step-Down Regimen of Oral Prednisolone in Axial Spondyloarthritis: Result of a Double-Blind Randomized Controlled Trial (COBRA-AS Study)

Authors: Mishra, D., Dhir, V., Naidu, G.S.R.S.N.K., Khullar, A., Kumar, V...
Journal: Rheumatology

Objectives: To evaluate the efficacy and safety of a step-down regimen of oral prednisolone over 24 weeks in patients of axial SpA (axSpA). Methods: This proof-of-concept double-blind randomized controlled trial enrolled patients with active axSpA (BASDAI ≥4) having predominantly axial disease (≤1 active joint currently) and...

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Cited Boster Product(s): Human TNF Alpha ELISA Kit PicoKine™ (EK0525); Human IL-6 ELISA Kit PicoKine™ (EK0410); Human MMP-3 ELISA Kit PicoKine™ (EK0461); Human Sclerostin/SOST ELISA Kit PicoKine™ (EK0968)

miR‐375 Induces Adipogenesis Through Targeting Erk1 in Pancreatic Duct Cells Under the Influence of Sodium Palmitate

Authors: Gezginci-Oktayoglu, S., Sancar, S., Karatug-Kacar, A., & Bolkent, S.
Journal: Journal of Cellular Physiology

The goal of this study was to research long‐term saturated fatty acid overexposure that can induce differentiation of pancreatic duct cells into adipocytes and also into β‐cells. The important findings can be summarized as follows: (i) adipogenesis and early stage β‐cell differentiation were stimulated in duct cells under...

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Cited Boster Product(s): Anti-Leptin Antibody Picoband™ (A00479-3)