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Research Spotlight - August 2023
Welcome to this month's Research Spotlight where we delve into an array of exciting scientific discoveries!
For the field of neuroscience, scientists examined the significance of G3BP2-Tau interaction for Tau aggregation as well as the role of SMN for neurodegeneration. In gastroenterology, researchers presented modified prebiotic-based probiotics as a novel approach for treating colitis. Furthermore, another study offered insights into the connections between gut microbiota and diabetic polyneuropathy.
Turning to oncology, scientists investigated circular RNA variants in glioblastoma, which hold promise for diagnostics and treatment. In this issue, we also highlight discoveries like antioxidant mitoquinone, innovative extracellular vesicle-packaged ILK, α-tubulin acetylation's importance, and an artificial niche creation.
These advancements bring fresh strategies to address diverse challenges in different fields. Scroll down to find out more!
Increased G3BP2-Tau Interaction in Tauopathies is a Natural Defense Against Tau Aggregation
Authors: Wang, C., Terrigno, M., Li, J., Distler, T., Pandya, N.J., Ebeling, M…
Journal: Neuron
Many RNA-binding proteins (RBPs), particularly those associated with RNA granules, promote pathological protein aggregation in neurodegenerative diseases. Here, we demonstrate that G3BP2, a core component of stress granules, directly interacts with Tau and inhibits Tau aggregation. In the human brain, the interaction of G3BP2...
Cited Boster Product(s): Anti-FOX3/NeuN Rbfox3 Antibody (M11954-3)
Modified Prebiotic-Based “Shield” Armed Probiotics with Enhanced Resistance of Gastrointestinal Stresses and Prolonged Intestinal Retention for Synergistic Alleviation of Colitis
Authors: Xie, A., Ji, H., Liu, Z., Wan, Y., Zhang, X., Xiong, H., Nie, S.P., Wan, H.
Journal: ACS Nano
Oral administration of probiotics is a promising method to alleviate inflammatory bowel diseases (IBDs). However, gastrointestinal environmental sensitivity and inferior intestinal colonization of probiotics hinder the alleviation effect. Here, we developed a simple yet effective modified prebiotic-based “shield” (Fe-TA@mGN) composed...
Cited Boster Product(s): Mouse MPO/Myeloperoxidase ELISA Kit PicoKine® (EK0943)
Gut Microbiota Modulate Distal Symmetric Polyneuropathy in Patients With Diabetes
Authors: Yang, J., Yang, X., Wu, G., Huang, F., Shi, X., Wei, W., Zhang, Y…
Journal: Cell Metabolism
The pathogenic mechanisms underlying distal symmetric polyneuropathy (DSPN), a common neuropathy in patients with diabetes mellitus (DM), are not fully understood. Here, we discover that the gut microbiota from patients with DSPN can induce a phenotype exhibiting more severe peripheral neuropathy in db/db mice. In a randomized...
Cited Boster Product(s): Goat Anti-Rabbit IgG (H+L) Secondary Antibody, Cy3 Conjugated (BA1032)
Circular RNA encoded MET variant promotes glioblastoma tumorigenesis
Authors: Zhong, J., Wu, X., Gao, Y., Chen, J., Zhang, M., Zhou, H., Yang, J…
Journal: Nature Communications
Activated by its single ligand, hepatocyte growth factor (HGF), the receptor tyrosine kinase MET is pivotal in promoting glioblastoma (GBM) stem cell self-renewal, invasiveness and tumorigenicity. Nevertheless, HGF/MET-targeted therapy has shown limited clinical benefits in GBM patients, suggesting hidden mechanisms of MET signalling...
Cited Boster Product(s): Anti-EGFR Antibody Picoband™ (A00023-4)
SMN Regulates GEMIN5 Expression and Acts As a Modifier of GEMIN5-Mediated Neurodegeneration
Authors: Fortuna, T.R., Kour, S., Chimata, A.V., Bühl, A.M., Anderson, E.N…
Journal: Acta Neuropathologica
GEMIN5 is essential for core assembly of small nuclear Ribonucleoproteins (snRNPs), the building blocks of spliceosome formation. Loss-of-function mutations in GEMIN5 lead to a neurodevelopmental syndrome among patients presenting with developmental delay, motor dysfunction, and cerebellar atrophy by perturbing SMN complex protein...
Cited Boster Product(s): Anti-Fruit Fly Rig Antibody (DZ41131); Anti-Fruit Fly Smn Antibody (DZ41018)
Extracellular Vesicle-Packaged ILK From Mesothelial Cells Promotes Fibroblast Activation in Peritoneal Fibrosis
Authors: Huang, Q., Sun, Y., Peng, L., Sun, J., Sha, Z., Lin, H., Li, Y., Li, C…
Journal: Journal of Extracellular Vesicles
Progressive peritoneal fibrosis and the loss of peritoneal function often emerged in patients undergoing long-term peritoneal dialysis (PD), resulting in PD therapy failure. Varieties of cell-cell communications among peritoneal cells play a significant role in peritoneal fibrogenesis. Extracellular vesicles (EVs) have been confirmed...
Cited Boster Product(s): HRP Conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) (BA1054); HRP Conjugated AffiniPure Goat Anti-Mouse IgG (H+L) (BA1050)
Triptolide with Hepatotoxicity and Nephrotoxicity Used in Local Delivery Treatment of Myocardial Infarction by Thermosensitive Hydrogel
Authors: Wang, K., Zhu, K., Zhu, Z., Shao, F., Qian, R., Wang, C., Dong, H…
Journal: Journal of Nanobiotechnology
Myocardial infarction (MI) resulting from coronary artery occlusion is the leading global cause of cardiovascular disability and mortality. Anti-inflammatory treatment plays an important role in MI treatment. Triptolide (TPL), as a Chinese medicine monomer, has a variety of biological functions, including anti-inflammatory, anti-tumor...
Cited Boster Product(s): Goat Anti-Rabbit IgG (H+L) Secondary Antibody, FITC Conjugated (BA1105); Goat Anti-Mouse IgG (H+L) Secondary Antibody, Cy3 Conjugated (BA1031); HRP Conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) (BA1054)
Antioxidant Mitoquinone Suppresses Benign Prostatic Hyperplasia by Regulating the AR–NLRP3 Pathway
Authors: Jin, B.R., Lim, C.Y., Kim, H.J., Lee, M., An, H.J.
Journal: Redox Biology
Mitoquinone (MitoQ), a mitochondria-targeted antioxidant, has been used to treat several diseases. The present study aimed to investigate the therapeutic effects of MitoQ in benign prostatic hyperplasia (BPH) models and their underlying molecular mechanisms. In this study, we determined that MitoQ inhibited dihydrotestosterone (DHT)...
Cited Boster Product(s): Anti-Prostate Specific Antigen/KLK3 Antibody Picoband™ (PB9259)
Oriented Artificial Niche Provides Physical-Biochemical Stimulations for Rapid Nerve Regeneration
Authors: Tan, M., Xu, W., Yan, G., Xu, Y., Xiao, Q., Liu, A., Peng, L.
Journal: Materials Today Bio
Skin wound is always accompanied with nerve damage, leading to significant sensory function loss. Currently, the functional matrix material based stem cell transplantation and in situ nerve regeneration are thought to be effective strategies, of which, how to recruit stem cells, retard senescence, and promote neural differentiation...
Cited Boster Product(s): Goat Anti-Mouse IgG (H+L) Secondary Antibody, FITC Conjugated (BA1101)
Matrix Stiffness‐Induced α‐Tubulin Acetylation is Required for Skin Fibrosis Formation Through Activation of Yes‐Associated Protein
Authors: Wen, D., Gao, Y., Liu, Y., Ho, C., Sun, J., Huang, L., Liu, Y., Li, Q…
Journal: MedComm
Skin fibrosis, a pathological process featured by fibroblast activation and extracellular matrix (ECM) deposition, makes a significant contribution to morbidity. Studies have identified biomechanics as the central element in the complex network of fibrogenesis that drives the profibrotic feedback loop. In this study, we found...
Cited Boster Product(s): Cytoplasmic And Nuclear Protein Extraction Kit (AR0106)
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