Research Spotlight - August 2022

We're happy to present our August issue of Research Spotlight, which highlights potential nano‐therapeutic strategies for targeting several diseases.

Scientists discussed innovative bio-inspired nanomaterials, such as surfactant functionalized nanorods and bioengineered bacterial outer membrane vesicles to treat K. pneumonia infection and cancer, respectively. Other biomedical studies demonstrated the improved mechanical/therapeutic characteristics of nanoparticles with nano-enzyme activity, electrospun nanofibers, and hydroxyapatite nanoparticles.

Researchers also investigated the interplay between various pathways and disease progression. A study indicated TMEM121 as an inhibitor of cervical cancer linked to multiple signaling pathways. Additionally, scientists explored the possibility of C. crustorum-derived bacteriocins (CCDB) as a dietary supplement for colitis.

Scroll down to learn more about these research studies!

TPGS-Based and S-Thanatin Functionalized Nanorods for Overcoming Drug Resistance in Klebsiella pneumonia

Authors: Wang, X., Xu, X., Zhang, S., Chen, N., Sun, Y., Ma, K., Hong, D., Li, L…
Journal : Nature Communications

Tigecycline is regarded as the last line of defense to combat multidrug-resistant Klebsiella pneumoniae. However, increasing utilization has led to rising drug resistance and treatment failure. Here, we design a D-alpha tocopheryl polyethylene glycol succinate-modified and S-thanatin peptide-functionalized nanorods based on calcium...

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Cited Boster Product(s): Mouse CRP / C Reactive Protein / PTX1 ELISA Kit PicoKine® (EK0977)

Interaction of Companilactobacillus crustorum MN047-Derived Bacteriocins with Gut Microbiota

Authors: Wang, T., Wang, S., Dong, S., Zhang, Y., Ishmael, M., Wang, S…
Journal: Food Chemistry

Companilactobacillus crustorum MN047-derived bacteriocins (CCDB) have inhibitory effects on the growth of pathogens. In this study, a pectin/zein beads delivery system was used to investigate the effects of CCDB on the dextran sulfate sodium-induced colitis in mice. The focus was given on aspects linked with the gut microbiota...

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Cited Boster Product(s): Anti-ZO1 Tight Junction Protein/TJP1 Antibody Picoband™ (PB9234)

Bacterial Outer Membrane Vesicles-Based Therapeutic Platform Eradicates Triple-Negative Breast Tumor by Combinational Photodynamic/Chemo-/Immunotherapy

Authors: Li, Y., Wu, J., Qiu, X., Dong, S., He, J., Liu, J., Xu, W., Huang, S…
Journal: Bioactive Materials

Bacterial outer membrane vesicles (OMVs) are potent immuno-stimulating agents and have the potentials to be bioengineered as platforms for antitumor nanomedicine. In this study, OMVs are demonstrated as promising antitumor therapeutics. OMVs can lead to beneficial M2-to-M1 polarization of macrophages and induce pyroptosis to enhance...

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Cited Boster Product(s): Mouse IL-6/Interleukin-6 ELISA Kit PicoKine® (EK0411); Mouse TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine® (EK0527); Mouse IFN Gamma / IFNG / Interferon Gamma ELISA Kit PicoKine® (EK0375)

Activation of Wnt/β-catenin Pathway Mitigates Blood–Brain Barrier Dysfunction in Alzheimer’s Disease

Authors: Wang, Q., Huang, X., Su, Y., Yin, G., Wang, S., Yu, B., Li, H., Qi, J…
Journal: Brain

Alzheimer’s disease (AD) is a neurodegenerative disorder that causes age-dependent neurological and cognitive declines. The treatments for AD pose a significant challenge, because the mechanisms of disease are not being fully understood. Malfunction of the blood-brain barrier (BBB) is increasingly recognized as a major contributor...

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Cited Boster Product(s): BCIP/ NBT Chromogenic Substrate Kit (AR1023)

Ceria nanoparticles prophylactic used for renal ischemia-reperfusion injury treatment by attenuating oxidative stress and inflammatory response

Authors: Zhou, L., Tang, S., Li, F., Wu, Y., Li, S., Cui, L., Luo, J., Yang, L…
Journal: Biomaterials

Renal ischemia-reperfusion (IR) injury (RIRI) is the leading cause of acute kidney injury (AKI), a common disease with high morbidity and mortality. However, due to the lack of effective diagnostic and therapeutic tools, patients have to resort to conservative treatment. To address this issue, we have developed a novel prophylactic strategy that involves...

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Cited Boster Product(s): Mouse IL-6/Interleukin-6 ELISA Kit PicoKine® (EK0411); Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine® (EK0394); Mouse TNF Alpha/Tumor Necrosis Factor PicoKine® Quick ELISA Kit (FEK0527)

DUSP2-mediated inhibition of tubular epithelial cell pyroptosis confers nephroprotection in acute kidney injury

Authors: Xiong, J., Ran, L., Zhu, Y., Wang, Y., Wang, S., Wang, Y., Lan, Q…
Journal: Theranostics

Rationale: Acute kidney injury (AKI) is pathologically characterized by renal tubular epithelial cell (RTEC) death and interstitial inflammation, while their pathogenesis remains incompletely understood. Dual-specificity phosphatase 2 (DUSP2) recently emerges as a crucial regulator of cell death and inflammation in a wide range...

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Cited Boster Product(s): Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine® (EK0394)

Aligned Electrospun poly(L-lactide) Nanofibers Facilitate Wound Healing by Inhibiting Macrophage M1 Polarization via the JAK-STAT and NF-κB Pathways

Authors: Xie, J., Wu, X., Zheng, S., Lin, K., Su, J.
Journal: Journal of Nanobiotechnology

Delayed wound healing remains a challenge, and macrophages play an important role in the inflammatory process of wound healing. Morphological changes in macrophages can affect their phenotype, but little is known about the underlying mechanism. Aligned electrospun nanofibers have natural advantages in modulating cell morphology...

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Cited Boster Product(s): Mouse IL-4/Interleukin-4 ELISA Kit PicoKine® (EK0405)

Exercise-Derived Peptide Protects Against Pathological Cardiac Remodeling

Authors: Yin, A., Yuan, R., Xiao, Q., Zhang, W., Xu, K., Yang, X., Yang, W…
Journal: eBioMedicine

Background: Exercise training protects the heart against pathological cardiac remodeling and confers cardioprotection from heart failure. However, the underlying mechanism is still elusive. Methods: An integrative analysis of multi-omics data of the skeletal muscle in response to exercise is performed to search for potential exerkine...

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Cited Boster Product(s): Human URB/CCDC80 ELISA Kit PicoKine® (EK1962)

Hydroxyapatite Nanoparticles Drive the Potency of Toll-Like Receptor 9 Agonist for Amplified Innate and Adaptive Immune Response

Authors: Zeng, Q., Wang, R., Hua, Y., Wu, H., Chen, X., Xiao, Y.C., Ao, Q…
Journal: Nano Research

The potency of Toll-like receptor 9 (TLR9) agonist to drive innate immune response was limited due to immune suppression or tolerance during TLR9 signaling activation in immune cells. Herein we addressed this problem by introducing hydroxyapatite nanoparticles (HANPs) to CpG ODN (CpG), a TLR9 agonist. The study revealed that HANPs...

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Cited Boster Product(s): 4% Paraformaldehyde (PFA) Solution In PBS (AR1068); DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) For Nucleic Acid Staining (AR1176)

Transmembrane Protein 121 as a Novel Inhibitor of Cervical Cancer Metastasis

Authors: Yang, B., Cai, Y., Zhu, P., Jiang, Z., Ao, J., Zhang, Q., Yuan, W...
Journal: Experimental and Therapeutic Medicine

Transmembrane protein 121 (TMEM121) is isolated from the chicken heart using subtraction hybridisation. A previous study by the authors indicated that TMEM121 is highly expressed in adult mouse hearts and acts as an inhibitor of pathological cardiac hypertrophy. In the present study, the association between TMEM121 and cancer...

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Cited Boster Product(s): Anti-E Cadherin 1/CDH1 Antibody Picoband™ (PB9561)