Research Spotlight – April 2020

Our April edition of Research Spotlight features 10 recent research discoveries from scientists whom Boster has served.

This month's selected research publications cover disease areas from acute liver injury to hepatocellular carcinoma to silocosis. The papers also investigate pretreatment TRL, ZBP1 biological function, triclocarban exposure, and several other research topics.

Scroll down to learn more about these new scientific discoveries.

Critical role of OX40 in drug‐induced acute liver injury

Authors: Zhang, C., Jin, H., Wang, Y., Li, C., Zhao, X., Li, Y., Shi, W., Tian, Y…
Journal: British Journal of Pharmacology

Background and Purpose: The innate and adaptive immune systems both play important roles in drug‐induced liver injury (DILI). However, the crosstalk between the innate and adaptive immunity in DILI is largely unknown. Extensive crosstalk is likely mandated by co‐stimulatory interactions between these immune systems. OX40 is a…

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Cited Boster Product(s): Mouse TNFRSF4/OX40 ELISA Kit PicoKine™ (EK0998)

Pretreatment tumor-related leukocytosis misleads positron emission tomography-computed tomography during lymph node staging in gynecological malignancies

Authors: Mabuchi, S., Komura, N., Sasano, T., Shimura, K., Yokoi, E., Kozasa, K…
Journal: Nature Communications

The accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG-PET/CT) can be influenced by the increased glycolytic activity of inflammatory lesions. Here, using clinical data obtained from gynecological cancer patients, tumor samples and animal models, we investigate the impact of…

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Cited Boster Product(s): Anti-MRP8/S100A8 Antibody Picoband™ (PB9742)

ZBP1 (DAI/DLM-1) promotes osteogenic differentiation while inhibiting adipogenic differentiation in mesenchymal stem cells through a positive feedback loop of Wnt/β-catenin signaling

Authors: Zhao, X., Xie, L., Wang, Z., Wang, J., Xu, H., Han, X., Bai, D. & Deng, P.
Journal: Bone Research

The lineage specification of mesenchymal stem/stromal cells (MSCs) is tightly regulated by a wide range of factors. Recently, the versatile functions of ZBP1 (also known as DAI or DLM-1) have been reported in the blood circulation and immune systems. However, the biological function of ZBP1 during the lineage specification of MSCs is...

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Cited Boster Product(s): RIPA Lysis Buffer (AR0105)

Alkaline Phosphatase-Triggered in Situ Formation of Silicon-Containing Nanoparticles for Fluorometric and Colorimetric Dual Channel Immunoassay

Authors: Chen, C., Zhao, D., Wang, B., Ni, P., Jiang, Y., Zhang, C., Yang, F., Lu, Y...
Journal: Analytical Chemistry

Enzyme-triggered in situ chromogenic and/or fluorogenic reactions under accessible conditions are significant for developing enzyme activity and related spectroscopic assays. Here, we describe a facile one-pot synthetic strategy to prepare silicon-containing nanoparticles with yellow-green fluorescence and orange-red color by mixing...

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Cited Boster Product(s): Antibody diluent buffer (AR1106-2)

Triclocarban exposure affects mouse oocyte in vitro maturation through inducing mitochondrial dysfunction and oxidative stress

Authors: Ding, Z.M., Ahmad, M.J., Meng, F., Chen, F., Wang, Y.S., Zhao, X.Z…
Journal: Environmental Pollution

Triclocarban (TCC), a broad-spectrum lipophilic antibacterial agent, is the main ingredient of personal and health care products. Nonetheless, its ubiquitous presence in the environment has been established to negatively affect the reproduction in humans and animals. In this work, we studied the possible toxic effects of TCC on mouse...

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Cited Boster Product(s): Goat Anti-Rabbit IgG (H+L) Secondary Antibody, Cy3 Conjugate (BA1032)

Opposite Nuclear Dynamics of Two FRH-Dominated Frequency Proteins Orchestrate Non-Rhythmic Conidiation in Beauveria bassiana

Authors: Tong, S.M., Wang, D.Y., Cai, Q., Ying, S.H. & Feng, M.G.
Journal: Cells

Non-rhythmic conidiation favors large-scale production of conidia serving as active ingredients of fungal insecticides, but its regulatory mechanism is unknown. Here, we report that two FREQUENCY (FRQ) proteins (Frq1/2) governed by a unique FRQ-interacting RNA helicase (FRH) orchestrate this valuable trait in Beauveria bassiana, an...

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Cited Boster Product(s): Goat Anti-Rabbit IgG (H+L) Secondary Antibody, HRP Conjugate (BA1054)

EGCG ameliorates neuronal and behavioral defects by remodeling gut microbiota and TotM expression in Drosophila models of Parkinson’s disease

Authors: Xu, Y., Xie, M., Xue, J., Xiang, L., Li, Y., Xiao, J., Xiao, G. & Wang, H.L.
Journal: The FASEB Journal

Parkinson’s disease (PD) is the second most common neurodegenerative disease. Eigallocatechin‐3‐gallate (EGCG), the major polyphenol in green tea, is known to exert a beneficial effect on PD patients. Although some mechanisms were suggested to underlie this intervention, it remains unknown if the EGCG‐mediated protection was achieved...

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Cited Boster Product(s): Goat Anti-Mouse IgG (H+L) Secondary Antibody, Cy3 Conjugate (BA1031)

Human Tissue Kallikrein 1 Improves Erectile Dysfunction of Streptozotocin-Induced Diabetic Rats by Inhibition of Excessive Oxidative Stress and Activation of the PI3K/AKT/eNOS Pathway

Authors: Luan, Y., Cui, K., Tang, Z., Ruan, Y., Liu, K., Wang, T., Chen, Z., Wang, S...
Journal: Oxidative Medicine and Cellular Longevity

Objective. To investigate the protective effects and mechanisms of human tissue kallikrein 1 (hKLK1) on type 1 diabetes mellitus- (DM-) induced erectile dysfunction in rats. Materials and Methods. The homozygous transgenic rats (TGR) harboring the hKLK1 gene and age-matched wild-type Sprague Dawley rats (WTR) were involved, and...

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Cited Boster Product(s): DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) for nucleic acid staining (AR1176)

Hepatocellular carcinoma: gene expression profiling and regulation of xenobiotic-metabolizing cytochromes P450

Authors: Nekvindova, J., Mrkvicova, A., Zubanova, V., Vaculovac, A.H...
Journal: Biochemical Pharmacology

Hepatocellular carcinoma (HCC) remains a highly prevalent and deadly disease, being among the top causes of cancer-related deaths worldwide. Despite the fact that the liver is the major site of biotransformation, studies on drug metabolizing enzymes in HCC are scarce. It is known that malignant transformation of hepatocytes leads to...

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Cited Boster Product(s) : Anti-Cytochrome P450 1A2 Monoclonal Antibody (M00598)

Silica particles disorganize the polarization of pulmonary macrophages in mice

Authors: Zhao, Y., Hao, C., Bao, L., Wang, D., Li, Y., Qu, Y., Ding, M., Zhao, A...
Journal: Ecotoxicology and Environmental Safety

Silicosis is a fatal fibrotic lung disease caused by long-term silica particle exposure, in which pulmonary macrophages play an important role. However, the relationship between macrophage polarization and silicosis remains unclear. We established an experimental silicosis mouse model to investigate macrophage polarization during...

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Cited Boster Product(s) : BCA Protein Assay Kit (AR0146)