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Product Info Summary
| SKU: | A05693 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-ZIP6 SLC39A6 Antibody
View all LIV-1/Zip6 Antibodies
SKU/Catalog Number
A05693
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-ZIP6 SLC39A6 Antibody (Catalog # A05693). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
ZIP6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-ZIP6 SLC39A6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05693)
Host
Rabbit
Contents
ZIP6 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
ZIP6 antibody was raised against a 16 amino acid synthetic peptide near the center of human ZIP6. The immunogen is located within amino acids 430 - 480 of ZIP6.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This antibody is predicted to not cross-react with other Ras-related proteins
Reactive Species
A05693 is reactive to SLC39A6 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
85047 MW
Background of LIV-1/Zip6
The zinc transporter ZIP6, also known as SLC39A6, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP6 was initially identified as LIV-1, an estrogen-regulated gene that has been implicated in metastatic breast cancer. Elevated ZIP6 expression has also been reported in human cervical cancer and the HeLa cell line; down-regulation of ZIP6 expression in HeLa by RNAi inhibited cell proliferation, colony formation, migration and invasiveness, as well as decreasing Snail and Slug levels, suggesting ZIP6 plays a regulatory role on the ERK1/2-Snail/Slug pathway.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A05693 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ZIP6 antibody can be used for detection of ZIP6 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of ZIP6 in mouse lung tissue lysate with ZIP6 antibody at 1 μg/mL.
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Immunohistochemistry of ZIP6 in mouse lung tissue with ZIP6 antibody at 5 μg/mL.
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Immunofluorescence of ZIP6 in mouse lung tissue with ZIP6 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SLC39A6 (Source: Uniprot.org, NCBI)
Gene Name
SLC39A6
Full Name
Zinc transporter ZIP6
Weight
85047 MW
Superfamily
ZIP transporter (TC 2.A.5) family
Alternative Names
LIV-1, LIV1, ZIP6, Zinc transporter ZIP6, Estrogen-regulated protein LIV-1, ZIP-6 SLC39A6 LIV-1, ZIP6 solute carrier family 39 member 6 zinc transporter ZIP6|LIV-1 protein, estrogen regulated|ZIP-6|estrogen-regulated protein LIV-1|solute carrier family 39 (metal ion transporter), member 6|solute carrier family 39 (zinc transporter), member 6|zrt- and Irt-like protein 6
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SLC39A6, check out the SLC39A6 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SLC39A6: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-ZIP6 SLC39A6 Antibody (A05693)
Hello CJ!
A05693 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Shen R, Xie F, Shen H, Liu Q, Zheng T, Kou X, Wang D, Yang J. Plos One. 2013;8(2):E56542. Doi: 10.1371/Journal.Pone.0056542. Epub 2013 Feb 20. Negative Correlation Of Liv-1 And E-Cadherin Expression In Hepatocellular Carcinoma Cells.
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