This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Zinc finger protein ZIC 2.
Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual goals. Its transcriptional activity is repressed by MDFIC.
Human | |
---|---|
Gene Name: | ZIC2 |
Uniprot: | O95409 |
Entrez: | 7546 |
Belongs to: |
---|
GLI C2H2-type zinc-finger protein family |
HPE5Zic family member 2 (odd-paired Drosophila homolog); Zic family member 2 (odd-paired homolog, Drosophila); Zinc finger protein of the cerebellum 2; zinc finger protein ZIC 2
Mass (kDA):
55.006 kDA
Human | |
---|---|
Location: | 13q32.3 |
Sequence: | 13; NC_000013.11 (99981784..99986765) |
Nucleus. Cytoplasm. Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus (By similarity).
PMID: 9771712 by Brown S.A., et al. Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired.
PMID: 10984499 by Yang Y., et al. ZIC2 and Sp3 repress Sp1-induced activation of the human D1A dopamine receptor gene.