Anti-XRCC2 (F240) Antibody

Product Name

Anti-XRCC2 (F240) Antibody

View all XRCC2 Antibodies

SKU/Catalog Number

A02138-1

Size

100ul

Form

Liquid

Description

Boster Bio Anti-XRCC2 (F240) Antibody catalog # A02138-1. Tested in IHC applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-XRCC2 (F240) Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02138-1)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human XRCC2.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A02138-1 is reactive to XRCC2 in Human, Mouse, Rat

Applications

A02138-1 is guaranteed for IHC Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

31956 MW

Background of XRCC2

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.

JP Scott, Blood, Oct 1981; 58: 665 - 669.
G Chevalier, Am. J. Pathol., Jun 1998; 152: 1563.
R Williams, J. Biol. Chem., Aug 1993; 268: 18213 - 18217.
Michael R. Ladomery, J. Biol. Chem., Dec 1999; 274: 36520.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

IHC: 1:50-1:200

Validation Images & Assay Conditions

There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.

Gene/Protein Information For XRCC2 (Source: Uniprot.org, NCBI)

Alternative Names

DKFZp781P0919; DNA repair protein XRCC2; X-ray repair complementing defective repair in Chinese hamster cells 2; X-ray repair cross-complementing protein 2; X-ray repair, complementing defective, repair in Chinese hamster XRCC2 FANCU, POF17, SPGF50 X-ray repair cross complementing 2 DNA repair protein XRCC2|X-ray repair complementing defective repair in Chinese hamster cells 2|X-ray repair cross-complementing protein 2|epididymis secretory sperm binding protein

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