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Product Info Summary
| SKU: | A10230 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Uroplakin-1b UPK1B Antibody
View all Uroplakin Ib Antibodies
SKU/Catalog Number
A10230
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Uroplakin-1b UPK1B Antibody (Catalog # A10230). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
UPK1B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Uroplakin-1b UPK1B Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10230)
Host
Rabbit
Contents
UPK1B Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
UPK1B antibody was raised against a 17 amino acid synthetic peptide near the center of human UPK1B. The immunogen is located within amino acids 110 - 160 of UPK1B.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of UPK1B are known to exist; this antibody will recognize both isoforms. UPK1B antibody is predicted to not cross-react with other tetraspanin protein family members.
Reactive Species
A10230 is reactive to UPK1B in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
29643 MW
Background of Uroplakin Ib
Uroplakin-1B (UPK1B) is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. UPK1B is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins and may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A10230 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
UPK1B antibody can be used for detection of UPK1B by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of UPK1B in human kidney tissue lysate with UPK1B antibody at 1 μg/mL in the (A) absence and (B) presence of blocking peptide.
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Immunohistochemistry of UPK1B in human bladder tissue with UPK1B antibody at 5 μg/mL.
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Immunofluorescence of UPK1B in human bladder muscle tissue with UPK1B antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For UPK1B (Source: Uniprot.org, NCBI)
Gene Name
UPK1B
Full Name
Uroplakin-1b
Weight
29643 MW
Superfamily
tetraspanin (TM4SF) family
Alternative Names
UPIB, UPK1, TSPAN20, Uroplakin-1b, Tetraspanin-20, UP1b UPK1B TSPAN20, UPIB, UPK1 uroplakin 1B uroplakin-1b|UP1b|tetraspan|tetraspanin-20|tspan-20|uroplakin Ib
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on UPK1B, check out the UPK1B Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for UPK1B: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Uroplakin-1b UPK1B Antibody (A10230)
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