Anti-UNC45A Antibody (Monoclonal, AbS1)

Product Name

Anti-UNC45A Antibody (Monoclonal, AbS1)

View all UNC45A Antibodies

SKU/Catalog Number

M08608

Size

50μg/vial

Form

Liquid

Description

Boster Bio Anti-UNC45A Antibody (Monoclonal, AbS1) catalog # M08608. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-UNC45A Antibody (Monoclonal, AbS1) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M08608)

Host

Mouse

Contents

Each vial contains 50% glycerol and 0.09% sodium azide.

Clonality

Monoclonal

Clone Number

AbS1

Isotype

IgG1

Immunogen

Recombinant human UNC45.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

Detects ~20kDa. Does not cross-react with αB-crystallin, βL-crystallin, ΒH- crystallin, γ-crystallin, HSP25, HSP27 or HSP47 proteins.

Reactive Species

M08608 is reactive to UNC45A in Human, Mouse, Rat

Reconstitution

Observed Molecular Weight

68 kDa

Calculated molecular weight

103077 MW

Background of UNC45A

Heat shock protein 47, also known as SERPINH1 or HSP47, is a serpin which serves as a human chaperone protein for collagen. This protein is a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. The protein localizes to the endoplasmic reticulum lumen and binds collagen; thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis. It has been found that HSP47 monitors the integrity of the triple helix of type I procollagen at the ER/cis-Golgi boundary and, when absent, the rate of transit from the ER to the Golgi is increased and the helical structure is compromised.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

M08608 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:1, 000, colorimetric, Human, Mouse, Rat

Validation Images & Assay Conditions

Gene/Protein Information For UNC45A (Source: Uniprot.org, NCBI)

Alternative Names

Protein unc-45 homolog A;Unc-45A;GCUNC-45;Smooth muscle cell-associated protein 1;SMAP-1;UNC45A;SMAP1; UNC45A GC-UNC45, GCUNC-45, GCUNC45, IRO039700, SMAP-1, SMAP1, UNC-45A unc-45 myosin chaperone A protein unc-45 homolog A|general cell UNC45|smooth muscle cell associated protein-1|unc-45 homolog A

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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