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Product Info Summary
| SKU: | A01472-3 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-TRPC3 Antibody
SKU/Catalog Number
A01472-3
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TRPC3 Antibody (Catalog # A01472-3). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TRPC3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-TRPC3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01472-3)
Host
Rabbit
Contents
TRPC3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TRPC3 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human TRPC3. The immunogen is located within amino acids 710 - 760 of TRPC3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
TRPC3 antibody is human, mouse and rat reactive. At least four isoforms are known to exist; this antibody will detect the three largest isoforms. TRPC3 antibody is predicted to not cross-react with TRPC6.
Reactive Species
A01472-3 is reactive to TRPC3 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
96009 MW
Background of TRPC3
The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. TRPC3 encodes a Ca2+-permeant channel that is agonist-activated but not store-operated or directly receptor-activated. TRPC3 physically interacts with TRPC6 and TRPC7 and forms functional tetrameric channels.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01472-3 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TRPC3 antibody can be used for the detection of TRPC3 by Western blot at 1 - 2 μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TRPC3 in human cerebellum tissue lysate with TRPC3 antibody at (A) 1 and (B) 2 μg/ml.
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Immunohistochemistry of TRPC3 in human brain tissue with TRPC3 antibody at 2.5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TRPC3 (Source: Uniprot.org, NCBI)
Gene Name
TRPC3
Full Name
Short transient receptor potential channel 3
Weight
96009 MW
Superfamily
transient receptor (TC 1.A.4) family
Alternative Names
TRP3, TRP3, Short transient receptor potential channel 3, Transient receptor protein 3, TrpC3 TRPC3 SCA41, TRP3 transient receptor potential cation channel subfamily C member 3 short transient receptor potential channel 3|hTrp-3|transient receptor potential cation channel subfamily C member 3 variant c|transient receptor protein 3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TRPC3, check out the TRPC3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TRPC3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TRPC3 Antibody (A01472-3)
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