Anti-TrkCT1 NTRK3 Antibody

Product Name

Anti-TrkCT1 NTRK3 Antibody

View all TrkC Antibodies

SKU/Catalog Number

A02502

Size

100ug

Form

Liquid (sterile filtered)

Description

Boster Bio Anti-TrkCT1 NTRK3 Antibody (Catalog # A02502). Tested in ELISA, IP, WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening. (Ship on dry ice.)

Cite This Product

Anti-TrkCT1 NTRK3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02502)

Host

Rabbit

Contents

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide

Clonality

Polyclonal

Isotype

IgG

Immunogen

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the carboxyl terminus of mouse TrkCT1 protein.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A02502 is reactive to NTRK3 in Human, Mouse

Reconstitution

Observed Molecular Weight

42 kDa

Calculated molecular weight

94428 MW

Background of TrkC

This antibody is suitable for Cancer, Immunology and Nuclear Signaling research. TrkCT1, also named neurotrophic tyrosine kinase receptor type 3 (Ntrk3) non-catalytic isoform 2, is a non-catalytic isoform of TrkC, the high affinity receptor for Neurotrophin-3 (NT-3). This isoform lacks the kinase domain that is responsible for signaling by the full-length isoform.  TrkCT1 is the product of an alternative splicing of Ntrk3 that leaves the extracellular and transmembrane domains intact but includes a shorter intracellular domain encoded by exons 13b and 14b. Recent studies indicate that the short cytoplasmic tail binds the scaffold protein Tamalin in a ligand-dependent manner and further activates the Arf6–Rac1 signaling pathway. Isoform 3 transcripts are readily detected early during embryogenesis and are expressed predominantly in adult brain and gonads.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A02502 is guaranteed for ELISA, IP, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

ELISA: 1:5,000 - 1:20,000
IP: 1 μg
WB: 1:1,000 - 1:10,000

Validation Images & Assay Conditions

Gene/Protein Information For NTRK3 (Source: Uniprot.org, NCBI)

Alternative Names

TrkCT1, Ntrk3, TrkCT-1, NT-3 growth factor receptor, GP145-TrkC, Trk-C, ETV6 NTRK3 fusion, GP145 TrkC, GP145TrkC, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, TrkC NC2 NTRK3 GP145-TrkC, TRKC, gp145(trkC) neurotrophic receptor tyrosine kinase 3 NT-3 growth factor receptor|ETS related protein-neurotrophic receptor tyrosine kinase fusion protein|ETV6-NTRK3 fusion|neurotrophic tyrosine kinase, receptor, type 3|tyrosine kinase receptor C

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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