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Product Info Summary
| SKU: | A01414 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-TRB3 TRIB3 Antibody
SKU/Catalog Number
A01414
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TRB3 TRIB3 Antibody (Catalog # A01414). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TRB3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-TRB3 TRIB3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01414)
Host
Rabbit
Contents
TRB3 antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TRB3 antibody was raised against a 17 amino acid peptide near the center of human TRB3. The immunogen is located within amino acids 100 - 150 of TRB3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
TRB3 antibody is human, mouse and rat reactive. At least two isoforms of TRB3 are known to exist; this antibody will detect both isoforms.
Reactive Species
A01414 is reactive to TRB3 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
39578 MW
Background of TRIB3
TRB3 was initially identified as a novel kinase-like gene that was overexpressed in multiple human tumors and regulated by hypoxia (1). In the liver, TRB3 binds and inhibits AKT activity, leading to impaired insulin signaling (2), whereas in adipose tissue TRB3 is involved in the regulation of fatty acid oxidation through ubiquitination of Acetyl-CoA carboxylase (3). Endoplasmic reticulum (ER) stress induces TRB3 expression in skeletal muscle, leading to a decrease in insulin signaling and glucose uptake, suggesting that inhibition of TRB3 expression may be a potential therapeutic treatment for managing insulin resistance (4).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01414 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TRB3 antibody can be used for detection of TRB3 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TRB3 in mouse kidney tissue lysate with TRB3 antibody at (A) 1 and (B) 2 μg/ml.
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Immunohistochemistry of TRB3 in mouse liver tissue with TRB3 antibody at 5 μg/mL.
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Immunofluorescence of TRB3 in mouse liver tissue with TRB3 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TRB3 (Source: Uniprot.org, NCBI)
Gene Name
TRB3
Full Name
Tribbles homolog 3
Weight
39578 MW
Superfamily
protein kinase superfamily
Alternative Names
Tribbles homolog 3, tribbles pseudokinase 3, TRIB3, NIPK, SINK, SKIP3, C20orf97 TRIB3 C20orf97, NIPK, SINK, SKIP3, TRB3 tribbles pseudokinase 3 tribbles homolog 3|TRB-3|neuronal cell death inducible putative kinase|p65-interacting inhibitor of NF-kappa-B|p65-interacting inhibitor of NF-kappaB
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TRB3, check out the TRB3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TRB3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TRB3 TRIB3 Antibody (A01414)
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No publications found for A01414
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