Anti-Transportin-3 TNPO3 Antibody

Product Name

Anti-Transportin-3 TNPO3 Antibody

View all TNPO3 Antibodies

SKU/Catalog Number

A03407

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Transportin-3 TNPO3 Antibody (Catalog # A03407). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

TNPO3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-Transportin-3 TNPO3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03407)

Host

Rabbit

Contents

TNPO3 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

TNPO3 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human TNPO3. The immunogen is located within amino acids 140 - 190 of TNPO3.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

Two alternatively spliced transcript variants have been observed.

Reactive Species

A03407 is reactive to TNPO3 in Human, Mouse, Rat

Applications

A03407 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

104203 MW

Background of TNPO3

TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

TNPO3 antibody can be used for detection of TNPO3 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot analysis of TNPO3 in HeLa cell lysate with TNPO3 antibody at 0.5 μg/mL.

Gene/Protein Information For TNPO3 (Source: Uniprot.org, NCBI)

Alternative Names

imp12; MTR10A; transportin 3; transportin-3 TNPO3 IPO12, LGMD1F, LGMDD2, MTR10A, TRN-SR, TRN-SR2, TRNSR transportin 3 transportin-3|imp12|importin 12|limb girdle muscular dystrophy 1F (autosomal dominant)|transportin-SR

For more info on TNPO3, check out the TNPO3 Infographic

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In this infographic, you will see the following information for TNPO3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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