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Product Info Summary
| SKU: | A03407 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-Transportin-3 TNPO3 Antibody
SKU/Catalog Number
A03407
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Transportin-3 TNPO3 Antibody (Catalog # A03407). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TNPO3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Transportin-3 TNPO3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03407)
Host
Rabbit
Contents
TNPO3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TNPO3 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human TNPO3. The immunogen is located within amino acids 140 - 190 of TNPO3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Two alternatively spliced transcript variants have been observed.
Reactive Species
A03407 is reactive to TNPO3 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
104203 MW
Background of TNPO3
TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A03407 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TNPO3 antibody can be used for detection of TNPO3 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TNPO3 in HeLa cell lysate with TNPO3 antibody at 0.5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TNPO3 (Source: Uniprot.org, NCBI)
Gene Name
TNPO3
Full Name
Transportin-3
Weight
104203 MW
Alternative Names
IPO12, TRNSR, LGMD1F, MTR10A, TRN-SR, TRN-SR2, IPO12, Transportin-3, Importin-12, Imp12 TNPO3 IPO12, LGMD1F, LGMDD2, MTR10A, TRN-SR, TRN-SR2, TRNSR transportin 3 transportin-3|imp12|importin 12|limb girdle muscular dystrophy 1F (autosomal dominant)|transportin-SR
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TNPO3, check out the TNPO3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TNPO3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Transportin-3 TNPO3 Antibody (A03407)
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