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Product Info Summary
| SKU: | A05347 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Transmembrane protein 18 TMEM18 Antibody
SKU/Catalog Number
A05347
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Transmembrane protein 18 TMEM18 Antibody (Catalog # A05347). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TMEM18 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Transmembrane protein 18 TMEM18 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05347)
Host
Rabbit
Contents
TMEM18 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TMEM18 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TMEM18. The immunogen is located within the last 50 amino acids of TMEM18.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Multiple isoforms of GLS2 are known to exist.
Reactive Species
A05347 is reactive to TMEM18 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
16265 MW
Background of TMEM18
Recent studies have examined how overexpression of certain genes enhances the tropism of neural stem cells (NSCs) for gliomas. Overexpression of Transmembrane protein 18 (TMEM18) provides NSCs and neural precursors an increased migration capacity towards glioblastoma cells in vitro and in the rat brain, while functional inactivation of the gene resulted in an almost complete loss of migration activity, suggesting that TMEM18 could be a potential target in NSC-based glioma therapy. Other recent results suggest that among others, the TMEM18 loci is associated with higher than normal body mass index (BMI) and obesity, indicating there may be a CNS-related role in predisposition to obesity. Multiple isoforms of TMEM18 are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A05347 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TMEM18 antibody can be used for detection of TMEM18 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TMEM18 in rat brain lysate with TMEM18 antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunohistochemistry of TMEM18 in mouse brain tissue with TMEM18 antibody at 2.5 μg/mL.
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Immunofluorescence of TMEM18 in Mouse Brain cells with TMEM18 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TMEM18 (Source: Uniprot.org, NCBI)
Gene Name
TMEM18
Full Name
Transmembrane protein 18
Weight
16265 MW
Superfamily
TMEM18 family
Alternative Names
Transmembrane protein 18 TMEM18 lncND transmembrane protein 18 transmembrane protein 18
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TMEM18, check out the TMEM18 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TMEM18: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Transmembrane protein 18 TMEM18 Antibody (A05347)
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