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Product Info Summary
| SKU: | M02229 |
|---|---|
| Size: | 100ug/vial |
| Reactive Species: | Human, Monkey, Mouse, Rabbit, Rat |
| Host: | Mouse |
| Application: | IHC, WB |
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Product info
Product Name
Anti-Transglutaminase II (TGM2) Monoclonal Antibody
View all Transglutaminase 2/TGM2 Antibodies
SKU/Catalog Number
M02229
Size
100ug/vial
Form
Liquid
Description
Boster Bio Anti-Transglutaminase II (TGM2) Monoclonal Antibody (Catalog # M02229). Tested in WB, IHC applications. This antibody reacts with Human, Monkey, Rabbit, Mouse, Rat.
Storage & Handling
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Cite This Product
Anti-Transglutaminase II (TGM2) Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M02229)
Host
Mouse
Contents
Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Clonality
Monoclonal
Clone Number
Clone: SPM358
Isotype
IgG1, kappa
Immunogen
Recombinant full-length human TGM2 protein
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Does not cross-react with primate, avian or amphibian GR.
Reactive Species
M02229 is reactive to TGM2 in Human, Monkey, Mouse, Rabbit, Rat
Reconstitution
Reconstitute with distilled water.
Observed Molecular Weight
68 kDa
Calculated molecular weight
77329 MW
Background of Transglutaminase 2/TGM2
Recognizes a 77-85kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M02229 is guaranteed for IHC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.
Validation Images & Assay Conditions
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Formalin-fixed, paraffin-embedded human Placenta stained with Anti-Transglutaminase II Mouse Monoclonal Antibody (SPM358).
Protein Target Info & Infographic
Gene/Protein Information For TGM2 (Source: Uniprot.org, NCBI)
Gene Name
TGM2
Full Name
Protein-glutamine gamma-glutamyltransferase 2
Weight
77329 MW
Superfamily
transglutaminase superfamily
Alternative Names
Protein-glutamine gamma-glutamyltransferase 2;2.3.2.13;Tissue transglutaminase;Transglutaminase C;TG (C);TGC;TGase C;Transglutaminase H;TGase H;Transglutaminase-2;TGase-2;TGM2; TGM2 TG(C), TGC transglutaminase 2 protein-glutamine gamma-glutamyltransferase 2|C polypeptide, protein-glutamine-gamma-glutamyltransferase|TGase C|TGase H|TGase-2|tissue transglutaminase|transglutaminase C|transglutaminase H
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TGM2, check out the TGM2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TGM2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Transglutaminase II (TGM2) Monoclonal Antibody (M02229)
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