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Product Info Summary
| SKU: | A15150 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, WB |
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Product info
Product Name
Anti-TMEM38A Antibody
SKU/Catalog Number
A15150
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TMEM38A Antibody (Catalog # A15150). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TMEM38A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-TMEM38A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A15150)
Host
Rabbit
Contents
TMEM38A Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TMEM38A antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human TMEM38A. The immunogen is located within the last 50 amino acids of TMEM38A.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of SPATA4 are known to exist; this antibody will detect both isoforms. SPATA4 antibody is predicted to not cross-react with SPATA protein family members
Reactive Species
A15150 is reactive to Tmem38a in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
33260 MW
Background of Tmem38a
TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A15150 is guaranteed for ELISA, IF, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TMEM38A antibody can be used for detection of TMEM38A by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Positive Control
Validation Images & Assay Conditions
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Western blot analysis of TMEM38A in rat skeletal muscle tissue lysate with TMEM38A antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunofluorescence of TMEM38A in mouse skeletal muscle tissue with TMEM38A antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For Tmem38a (Source: Uniprot.org, NCBI)
Gene Name
Tmem38a
Full Name
Trimeric intracellular cation channel type A
Weight
33260 MW
Superfamily
TMEM38 family
Alternative Names
transmembrane protein 38ATRIC-AMGC3169; TRICA; trimeric intracellular cation channel type A Tmem38a|1110001E17Rik, AI413399, SPR-27, TRI, TRIC-A, mg33a|transmembrane protein 38A|trimeric intracellular cation channel type A|27 kDa sarcoplasmic reticulum protein|mitsugumin-33A
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Tmem38a, check out the Tmem38a Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Tmem38a: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TMEM38A Antibody (A15150)
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