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Product Info Summary
| SKU: | A14535 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-TLX3 Antibody
SKU/Catalog Number
A14535
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TLX3 Antibody (Catalog # A14535). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TLX3 antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-TLX3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A14535)
Host
Rabbit
Contents
TLX3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TLX3 antibody was raised against a 16 amino acid peptide near the amino terminus of human TLX3. The immunogen is located within the first 50 amino acids of TLX3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
TLX3 antibody is predicted to not cross-react with other TLX proteins.
Reactive Species
A14535 is reactive to TLX3 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
31867 MW
Background of Tlx3
The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX3, also known as homeobox11-like1 (HOX11L2), is a DNA-binding nuclear transcription factor that is expressed in a subset of the primary sensory nervous system. TLX3, along with the related TLX1, is a selector transcription factor that promotes an excitatory glutamatergic neuronal phenotype over an inhibitory GABAergic phenotype opposing LBX1 signals during dorsal spinal cord development. Chromosomal translocations of the TLX3 gene have been shown to result in some forms of T-cell acute lymphoblastic leukemia (T-ALL).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A14535 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TLX3 antibody can be used for detection of TLX3 by Western blot at 0.5 - 1 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TLX3 in human spleen tissue lysate with TLX3 antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunohistochemistry of TLX3 in human spleen tissue with TLX3 antibody at 2.5 μg/ml.
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Immunofluorescence of TLX3 in human spleen tissue with TLX3 antibody at 20 μg/ml.
Protein Target Info & Infographic
Gene/Protein Information For TLX3 (Source: Uniprot.org, NCBI)
Gene Name
TLX3
Full Name
T-cell leukemia homeobox protein 3
Weight
31867 MW
Alternative Names
RNX, HOX11L2, T-cell leukemia homeobox protein 3, Homeobox protein Hox-11L2 Tlx3|Hox11, Hox11l2, R, Rnx, Tlx1, Tlx1l2|T cell leukemia, homeobox 3|T-cell leukemia homeobox protein 3|homeo box 11-like 2|homeobox TLX-3|homeobox protein Hox-11L2|respiratory neuron homeobox protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TLX3, check out the TLX3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TLX3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TLX3 Antibody (A14535)
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