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Product Info Summary
| SKU: | A12896 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, ICC, WB |
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Product info
Product Name
Anti-TIAF TIAF1 Antibody
SKU/Catalog Number
A12896
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TIAF TIAF1 Antibody (Catalog # A12896). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse.
Storage & Handling
TIAF antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-TIAF TIAF1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A12896)
Host
Rabbit
Contents
TIAF Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TIAF antibody was raised against a 16 amino acid peptide near the amino terminus of human TIAF . The immunogen is located within the first 50 amino acids of TIAF.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Two alternatively spliced transcript variants encoding different isoforms have been identified.
Reactive Species
A12896 is reactive to TIAF in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
12414 MW
Background of TIAF1
TIAF-1 (TGFB1-induced anti-apoptotic factor 1), also known as MYO18A, is a TGFB1-induced anti-apoptotic factor that functions to inhibit the cytotoxic effects of TNF-alpha, TRADD and FADD. It localizes to the nucleus and significantly up-regulated in activated helper T lymphocytes (TH2) in chronic kidney and liver allograft rejection. Suppression of TIAF1 expression by siRNA prevents UV irradiation-mediated p53 phosphorylation and nuclear translocation. TIAF1 is essential in the p53- and WOX1-mediated cell death and shows an aggregation-dependent control of tumor progression and metastasis, and regulation of cell death.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A12896 is guaranteed for ELISA, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TIAF Antibody can be used for detection of TIAF by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TIAF in K562 cell lysate with TIAF antibody at 1 μg/mL.
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Immunocytochemistry of TIAF in K562 cells with TIAF antibody at 2.5 μg/ml.
Protein Target Info & Infographic
Gene/Protein Information For TIAF (Source: Uniprot.org, NCBI)
Gene Name
TIAF
Full Name
TGFB1-induced anti-apoptotic factor 1
Weight
12414 MW
Alternative Names
MAJN, SPR210, TGFB1-induced anti-apoptotic factor 1, 12 kDa TGF-beta-1-induced antiapoptotic factor TIAF1 MAJN, SPR210 TGFB1-induced anti-apoptotic factor 1 TGFB1-induced anti-apoptotic factor 1|12 kDa TGF-beta-1-induced antiapoptotic factor|TGF-beta-1-induced antiapoptotic factor 1|molecule associated with Jak-3 N-terminal
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TIAF, check out the TIAF Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TIAF: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TIAF TIAF1 Antibody (A12896)
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