Anti-Thiamin pyrophosphokinase 1 TPK1 Antibody

Product Name

Anti-Thiamin pyrophosphokinase 1 TPK1 Antibody

View all TPK1 Antibodies

SKU/Catalog Number

A05487

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Thiamin pyrophosphokinase 1 TPK1 Antibody catalog # A05487. Tested in WB applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Thiamin pyrophosphokinase 1 TPK1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05487)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human PTPRK protein.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A05487 is reactive to TPK1 in Human, Mouse, Rat

Applications

A05487 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

111 kDa

Calculated molecular weight

27265 MW

Background of TPK1

Isoform GANP:Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells By similarity. Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Isoform MCM3AP:Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation.

Nobuo Sakaguchi, J. Immunol., Apr 2005; 174: 4485 - 4494.
Kazuhiko Kuwahara, Blood, Apr 2000; 95: 2321 - 2328.
Y Kono, K Maeda, Genes Cells, Aug 2002; 7: 821 - 834.
Kazuhiko Kuwahara, PNAS, Aug 2001; 98: 10279.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:500-1:2000

Validation Images & Assay Conditions

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Figure 1. Western blotting validation for Anti-Thiamin pyrophosphokinase 1 TPK1 Antibody A05487

Western blot analysis of extracts of various cell lines

Gene/Protein Information For TPK1 (Source: Uniprot.org, NCBI)

Alternative Names

EC 2.7.6.2; HTPK1; Placental protein 20; PP20thiamine kinase; thiamin pyrophosphokinase 1; thiamine diphosphokinase; Thiamine pyrophosphokinase 1 TPK1 HTPK1, PP20, THMD5 thiamin pyrophosphokinase 1 thiamin pyrophosphokinase 1|placental protein 20|thiamine diphosphokinase|thiamine kinase

For more info on TPK1, check out the TPK1 Infographic

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In this infographic, you will see the following information for TPK1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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