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TBX5 Antibodies

AND TBX5 ELISA kits, TBX5 Proteins

Many biological assays use antibodies to detect TBX5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TBX5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TBX5 antibodies...

We validate the specificity of these antibodies to TBX5 by testing them on tissues known to express TBX5 positively and negatively. Browse below to find the TBX5 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TBX5 Infographic by Boster Bio

TBX5 protein infographic

All TBX5 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-TBX5 Monoclonal Antibody

Human

WB

$399
Cat # A00803
100μl

TBX5 (NM_000192) Human Over-expression Lysate

Human

$628
Cat # LS006910
100 µg

TBX5 Overview

Facts about T-box transcription factor TBX5.

TBX5 3D structure

TBX5 3D structure. Source: alphafold

T-box transcription factor TBX5 (TBX5)

DNA-binding protein which regulates the transcription of several genes and is involved in heart development and limb pattern formation (PubMed:25725155, PubMed:25963046, PubMed:29174768, PubMed:26917986, PubMed:27035640, PubMed:8988164). Binds to the core DNA motif of NPPA promoter (PubMed:26926761).

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Gene Information

Human
Gene Name:	TBX5
Uniprot:	Q99593
Entrez:	6910

Gene Information

Family

Belongs to:

No superfamily

Family

Alternative Names

HOS; T-box 5; T-box protein 5; T-box transcription factor TBX5; TBX5

Molecular Weight

Mass (kDA):
57.711 kDA

Molecular Weight

Genomic Context


Human

Location:	12q24.21
Sequence:	12; NC_000012.12 (114353911..114408708, complement)

Subcellular Localizations

Nucleus. Cytoplasm. Shuttles between the cytoplasm and the nucleus. Acetylation at Lys-339 promotes nuclear retention.

Subcellular Localization

Diseases

Holt-oram Syndrome
Congenital Heart Defects
Heart Diseases
Congenital Heart Disease
Limb Deformities, Congenital
Congenital Abnormality
Haploinsufficiency
Heart Septal Defects
Atrial Septal Defects
Limb Defect
Ventricular Septal Defects
Congenital Hand Deformities
Endocardial Cushion Defects

Infarction
Myocardial Infarction
Cardiac Arrhythmia
Malignant Neoplasms
Digeorge Syndrome
Hypoplasia
Neoplasms

Disease

Interacting Proteins

Gata4
NKX2-5
YAP1

Interacting Proteins

Pathways

Heart Development
Limb Development
Localization
Heart Formation
Cell Proliferation
Cardiac Conduction
Regeneration
Pathogenesis
Heart Morphogenesis
Eye Development
Fin Development
Cell Differentiation
Gastrulation

Cell Growth
Cell Migration
Pectoral Fin Development
Cell Cycle
Eye Morphogenesis
System Development
Cell Death

Pathways

PTMs

Phosphorylation
Acetylation

Methylation
Ubiquitination

Cleavage

Bosterbio | ELISA Kits, Antibodies, Antibody Company

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TBX5

References

PMID: 8988164 by Li Q.Y., et al. Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family.

PMID: 8988165 by Basson C.T., et al. Mutations in human TBX5 cause limb and cardiac malformation in Holt- Oram syndrome.