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Product Info Summary
| SKU: | A09202 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Tau-tubulin kinase 1 TTBK1 Antibody
SKU/Catalog Number
A09202
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Tau-tubulin kinase 1 TTBK1 Antibody (Catalog # A09202). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
TTBK1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Tau-tubulin kinase 1 TTBK1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09202)
Host
Rabbit
Contents
TTBK1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TTBK1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human TTBK1. The immunogen is located within amino acids 1190 - 1240 of TTBK1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Multiple isoforms of TTBK1 are known to exist. This antibody is predicted to not cross-react with TTBK2.
Reactive Species
A09202 is reactive to TTBK1 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
142737 MW
Background of TTBK1
Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer's disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A09202 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TTBK1 antibody can be used for detection of TTBK1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TTBK1 in Jurkat lysate with TTBK1 antibody at 1 μg/mL.
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Immunohistochemistry of TTBK1 in mouse brain tissue with TTBK1 antibody at 2.5 μg/mL.
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Immunofluorescence of TTBK1 in Human Brain tissue with TTBK1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TTBK1 (Source: Uniprot.org, NCBI)
Gene Name
TTBK1
Full Name
Tau-tubulin kinase 1
Weight
142737 MW
Superfamily
protein kinase superfamily
Alternative Names
BDTK, BDTK, KIAA1855, Tau-tubulin kinase 1, Brain-derived tau kinase TTBK1 BDTK tau tubulin kinase 1 tau-tubulin kinase 1|brain-derived tau kinase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TTBK1, check out the TTBK1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TTBK1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Tau-tubulin kinase 1 TTBK1 Antibody (A09202)
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