Product Info Summary
SKU: | A00570 |
---|---|
Size: | 100ul |
Reactive Species: | Human |
Host: | Rabbit |
Application: | ELISA, IHC, WB |
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Product info
Product Name
Anti-T-cell surface antigen CD2 CD2 Antibody
SKU/Catalog Number
A00570
Size
100ul
Form
Liquid
Description
Boster Bio Anti-T-cell surface antigen CD2 CD2 Antibody catalog # A00570. Tested in ELISA, IHC, WB applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-T-cell surface antigen CD2 CD2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00570)
Host
Rabbit
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human CD2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A00570 is reactive to CD2 in Human
Applications
A00570 is guaranteed for ELISA, IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
39448 MW
Background of CD2
Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes By similarity. Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.
Nagamine K., Nat. Genet. 17:393-398(1997).
Aaltonen J., Nat. Genet. 17:399-403(1997).
Hattori M., Nature 405:311-319(2000).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:500-1:2000
IHC-P 1:100-300
ELISA 1:20000
Validation Images & Assay Conditions
![a00570 anti t cell surface antigen cd2 cd2 antibody ihc testing 2 a00570 anti t cell surface antigen cd2 cd2 antibody ihc testing 2](https://www.bosterbio.com/media/catalog/product/a/0/a00570-anti-t-cell-surface-antigen-cd2-cd2-antibody-ihc-testing-2.jpg)
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Figure 2. Immunohistochemistry validation of CD2 using Anti-T-cell surface antigen CD2 CD2 Antibody (A00570).
Immunohistochemistry (IHC) analysis of paraffin-embedded Human Pancreas![a00570 anti t cell surface antigen cd2 cd2 antibody ihc testing 3 a00570 anti t cell surface antigen cd2 cd2 antibody ihc testing 3](https://www.bosterbio.com/media/catalog/product/a/0/a00570-anti-t-cell-surface-antigen-cd2-cd2-antibody-ihc-testing-3.jpg)
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Figure 3. Immunohistochemistry validation of CD2 using Anti-T-cell surface antigen CD2 CD2 Antibody (A00570).
Immunohistochemistry (IHC) analysis of paraffin-embedded Human Pancreas![a00570 anti t cell surface antigen cd2 cd2 antibody ihc testing 4 a00570 anti t cell surface antigen cd2 cd2 antibody ihc testing 4](https://www.bosterbio.com/media/catalog/product/a/0/a00570-anti-t-cell-surface-antigen-cd2-cd2-antibody-ihc-testing-4.jpg)
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Figure 4. Immunohistochemistry validation of CD2 using Anti-T-cell surface antigen CD2 CD2 Antibody (A00570).
Immunohistochemistry (IHC) analysis of paraffin-embedded Human Pancreas![a00570 anti t cell surface antigen cd2 cd2 antibody wb testing 1 a00570 anti t cell surface antigen cd2 cd2 antibody wb testing 1](https://www.bosterbio.com/media/catalog/product/a/0/a00570-anti-t-cell-surface-antigen-cd2-cd2-antibody-wb-testing-1.jpg)
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Figure 1. Western blotting validation for Anti-T-cell surface antigen CD2 CD2 Antibody A00570
Western Blot (WB) analysis of K562 cells using CD2 polyclonal antibody.Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
Protein Target Info & Infographic
Gene/Protein Information For CD2 (Source: Uniprot.org, NCBI)
Gene Name
CD2
Full Name
T-cell surface antigen CD2
Weight
39448 MW
Alternative Names
CD2 antigen (p50), sheep red blood cell receptor; CD2 antigen; CD2 molecule; CD2; Erythrocyte receptor; FLJ46032; LFA-2; LFA-3 receptor; lymphocyte-function antigen-2; Rosette receptor; SRBC; T11; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5 CD2 LFA-2, SRBC, T11 CD2 molecule T-cell surface antigen CD2|CD2 antigen (p50), sheep red blood cell receptor|LFA-3 receptor|T-cell surface antigen T11/Leu-5|erythrocyte receptor|lymphocyte-function antigen-2|rosette receptor
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CD2, check out the CD2 Infographic
![CD2 infographic](/media/images/gene-infographic-example.jpg)
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CD2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-T-cell surface antigen CD2 CD2 Antibody (A00570)
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