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Product Info Summary
| SKU: | A08882 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Syntaphilin SNPH Antibody
View all Syntaphilin Antibodies
SKU/Catalog Number
A08882
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Syntaphilin SNPH Antibody (Catalog # A08882). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Syntaphilin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Syntaphilin SNPH Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08882)
Host
Rabbit
Contents
Syntaphilin Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Syntaphilin antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human Syntaphilin. The immunogen is located within amino acids 80 - 130 of Syntaphilin.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Two isoforms of PRICKLE2 are known to exist. PRICKLE2 antibody is predicted to not cross-react with other PRICKLE protein family members.
Reactive Species
A08882 is reactive to SNPH in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
53537 MW
Background of Syntaphilin
Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function. Multiple isoforms are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A08882 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Syntaphilin antibody can be used for detection of Syntaphilin by Western blot at 2 - 4 μg/mL. Despite its predicted molecular weight, Syntaphilin usually migrates at higher molecular weight in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Syntaphilin in human brain tissue lysate with Syntaphilin antibody at (A) 2 and (B) 4 μg/mL.
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Immunohistochemistry of Syntaphilin in human brain with Syntaphilin antibody at 5 μg/mL.
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Immunofluorescence of Syntaphilin in Human Brain cells with Syntaphilin antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SNPH (Source: Uniprot.org, NCBI)
Gene Name
SNPH
Full Name
Syntaphilin
Weight
53537 MW
Alternative Names
bA314N13.5, KIAA0374, Syntaphilin SNPH syntaphilin syntaphilin
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SNPH, check out the SNPH Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SNPH: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Syntaphilin SNPH Antibody (A08882)
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