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Product Info Summary
| SKU: | A14531 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Synaptophysin-like protein 2 SYPL2 Antibody
SKU/Catalog Number
A14531
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Synaptophysin-like protein 2 SYPL2 Antibody (Catalog # A14531). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
SYPL2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Synaptophysin-like protein 2 SYPL2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A14531)
Host
Rabbit
Contents
SYPL2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
SYPL2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human SYPL. The immunogen is located within the last 50 amino acids of SYPL2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of SYPL2 are known to exist. SYPL2 antibody will not cross-react with SYPL1.
Reactive Species
A14531 is reactive to SYPL2 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
30156 MW
Background of Sypl2
SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family. SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle. SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function. Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A14531 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
SYPL2 antibody can be used for detection of SYPL2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of SYPL2 in human spleen tissue lysate with SYPL2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of SYPL2 in human spleen tissue with SYPL2 antibody at 2.5 μg/mL.
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Immunofluorescence of SYPL2 in Human Spleen cells with SYPL2 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SYPL2 (Source: Uniprot.org, NCBI)
Gene Name
SYPL2
Full Name
Synaptophysin-like protein 2
Weight
30156 MW
Superfamily
synaptophysin/synaptobrevin family
Alternative Names
MG29, Synaptophysin-like protein 2 Sypl2|AI552439, Mg29|synaptophysin-like 2|synaptophysin-like protein 2|mitsugumin 29
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SYPL2, check out the SYPL2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SYPL2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Synaptophysin-like protein 2 SYPL2 Antibody (A14531)
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