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Product Info Summary
| SKU: | A02345-2 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Stromal interaction molecule 2 STIM2 Antibody
SKU/Catalog Number
A02345-2
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Stromal interaction molecule 2 STIM2 Antibody (Catalog # A02345-2). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
STIM2 antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Stromal interaction molecule 2 STIM2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02345-2)
Host
Rabbit
Contents
STIM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
STIM2 antibody was raised against a 18 amino acid synthetic peptide from near the carboxy terminus of human STIM2. The immunogen is located within the last 50 amino acids of STIM2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms of Fibulin 3 are known to exist. This antibody is predicted to not cross-react with other Fibulin proteins.
Reactive Species
A02345-2 is reactive to STIM2 in Human, Mouse, Rat
Applications
A02345-2 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
83971 MW
Background of STIM2
In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites which act as the Ca++ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca++ entry. At least three isoforms of STIM2 are known to exist. This STIM2 antibody is predicted to have no cross-reactivity to STIM1.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
STIM2 antibody can be used for detection of STIM2 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of STIM2 in A-20 cell lysate with STIM2 antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunohistochemistry of STIM2 in human spleen tissue with STIM2 antibody at 2.5 μg/mL.
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Immunofluorescence of STIM2 in Human Spleen cells with STIM2 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For STIM2 (Source: Uniprot.org, NCBI)
Gene Name
STIM2
Full Name
Stromal interaction molecule 2
Weight
83971 MW
Alternative Names
FLJ39527; KIAA1482; stromal interaction molecule 2 STIM2 stromal interaction molecule 2 stromal interaction molecule 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on STIM2, check out the STIM2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for STIM2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Stromal interaction molecule 2 STIM2 Antibody (A02345-2)
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