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Product Info Summary
| SKU: | A10002 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Secernin-1 SCRN1 Antibody
View all Secernin-1 Antibodies
SKU/Catalog Number
A10002
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Secernin-1 SCRN1 Antibody (Catalog # A10002). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
SCRN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Secernin-1 SCRN1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10002)
Host
Rabbit
Contents
SCRN1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
SCRN1 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human SCRN1. The immunogen is located within amino acids 320 - 370 of SCRN1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
PDCL3 antibody is human, mouse and rat reactive. PDCL3 antibody is predicted to not cross-react with other members of the PDCL protein family.
Reactive Species
A10002 is reactive to SCRN1 in Human, Mouse, Rat
Applications
A10002 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
46382 MW
Background of Secernin-1
SCRN1 was first identified as a cytosolic protein that is involved in the regulation of exocytosis from peritoneal mast cells. More recent studies have shown that SCRN1 expression is upregulated in gastric cancer cell lines and may possess epitopes that could function as tumor-associated antigens, potentially providing targets for cancer vaccines in the treatment of gastric cancers. Another report indicates that decreased expression of SCRN1 via RNAi expression resulted in significantly lower rates of cell growth in colorectal cancer cell lines, and increased SCRN1 expression in patients with colorectal cancer correlated with poor prognosis, suggesting that SCRN1 may also be involved in the regulation of cell growth and might be useful as a prognostic tool.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
SCRN1 antibody can be used for detection of SCRN1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of SCRN1 in human kidney tissue lysate with SCRN1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of SCRN1 in human kidney tissue with SCRN1 antibody at 5 μg/mL.
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Immunofluorescence of SCRN1 in Human Kidney cells with SCRN1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SCRN1 (Source: Uniprot.org, NCBI)
Gene Name
SCRN1
Full Name
Secernin-1
Weight
46382 MW
Superfamily
peptidase C69 family
Alternative Names
KIAA0193SES1; secernin 1; secernin-1 SCRN1 SES1 secernin 1 secernin-1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SCRN1, check out the SCRN1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SCRN1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Secernin-1 SCRN1 Antibody (A10002)
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