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Product Info Summary
| SKU: | A02934 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-SCO1 Antibody
SKU/Catalog Number
A02934
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-SCO1 Antibody (Catalog # A02934). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
SCO1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-SCO1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02934)
Host
Rabbit
Contents
SCO1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
SCO1 antibody was raised against a 14 amino acid synthetic peptide from near the center of human SCO1. The immunogen is located within amino acids 100 - 150 of SCO1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
ANGPTL3 antibody is human, mouse and rat reactive. ANGPTL3 antibody is predicted not to cross-react with other ANGPTL family proteins.
Reactive Species
A02934 is reactive to SCO1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
33814 MW
Background of SCO1
Synthesis of cytochrome c oxidase 1 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO1 and SCO2 are dependent on copper ion binding. Mutations in either gene can lead to cytochrome c oxidase respiratory chain defects, with a missense mutation in human SCO1 (P174L) associated with a fatal neonatal hepatopathy when the second allele is also non-functional, suggesting the pathology is due to loss of function. It has been suggested that this mutation alters the SCO1 affinity for the copper (I) ion, thus impairing the efficiency of copper transfer to the cytochrome c oxidase. At least two isoforms of SCO1 are known to exist and both are recognized by the SCO1 antibody. This SCO1 antibody has no cross-reactivity to SCO2.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A02934 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
SCO1 antibody can be used for detection of SCO1 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of SCO1 in human brain tissue lysate with SCO1 antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunohistochemistry of SCO1 in human brain tissue with SCO1 antibody at 2.5 μg/mL.
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Immunofluorescence of SCO1 in Human Brain cells with SCO1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SCO1 (Source: Uniprot.org, NCBI)
Gene Name
SCO1
Full Name
Protein SCO1 homolog, mitochondrial
Weight
33814 MW
Superfamily
SCO1/2 family
Alternative Names
SCOD1, SCOD1, Protein SCO1 homolog, mitochondrial SCO1 MC4DN4, SCOD1 synthesis of cytochrome C oxidase 1 protein SCO1 homolog, mitochondrial|SCO cytochrome c oxidase assembly protein 1|SCO cytochrome oxidase deficient homolog 1|SCO1, cytochrome c oxidase assembly protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SCO1, check out the SCO1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SCO1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-SCO1 Antibody (A02934)
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