Product Info Summary
SKU: | A14041 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-SAPAP3 DLGAP3 Antibody
SKU/Catalog Number
A14041
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-SAPAP3 DLGAP3 Antibody (Catalog # A14041). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
SAPAP3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-SAPAP3 DLGAP3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A14041)
Host
Rabbit
Contents
SAPAP3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
SAPAP3 antibody was raised against a 18 amino acid synthetic peptide from near the carboxy terminus of human SAPAP3. The immunogen is located within the last 50 amino acids of SAPAP3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of TMEM135 are known to exist; this antibody will detect both isoforms.
Reactive Species
A14041 is reactive to DLGAP3 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
106040 MW
Background of DLGAP3
SAP90/PSD-95-associated protein 3 (SAPAP3, also known as DLGAP3) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP3 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). Both SAPAP3 protein and mRNA are targeted to dendrites, whereas SAPAP1, -2, and -4 mRNAs are detected mainly in cell bodies. Recent experiments have suggested that SAPAP3 may be involved in obsessive-compulsive disorder (OCD), as mice lacking SAPAP3 exhibited OCD-like symptoms which could be relieved by lentiviral-mediated selective expression of SAPAP3 in the striatum of SAPAP3-mutant mice. At least two isoforms are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A14041 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
SAPAP3 antibody can be used for detection of SAPAP3 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of SAPAP3 in rat brain tissue lysate with SAPAP3 antibody at (A) 1 (B) 2 μg/mL.
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Immunohistochemical staining of human brain tissue using SAPAP3 antibody at 2.5 μg/mL.
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Immunofluorescence of SAPAP3 in human brain tissue with SAPAP3 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For DLGAP3 (Source: Uniprot.org, NCBI)
Gene Name
DLGAP3
Full Name
Disks large-associated protein 3
Weight
106040 MW
Superfamily
SAPAP family
Alternative Names
DAP3, SAPAP3, DAP3, Disks large-associated protein 3, DAP-3 DLGAP3 DAP3, SAPAP3 DLG associated protein 3 disks large-associated protein 3|DAP-3|PSD-95/SAP90-binding protein 3|SAP90/PSD-95-associated protein 3|discs large homolog associated protein 3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on DLGAP3, check out the DLGAP3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for DLGAP3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-SAPAP3 DLGAP3 Antibody (A14041)
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