Anti-RMP URI1 Antibody

Product Name

Anti-RMP URI1 Antibody

View all URI Antibodies

SKU/Catalog Number

A05245

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-RMP URI1 Antibody (Catalog # A05245). Tested in WB, IHC applications. This antibody reacts with Human, Mouse.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-RMP URI1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05245)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from C-terminal of human RMP.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A05245 is reactive to URI1 in Human, Mouse

Reconstitution

Observed Molecular Weight

111 kDa

Calculated molecular weight

59832 MW

Background of URI

Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein. Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.

Van Leuven F., Genomics 54:511-520(1998).
Ota T., Nat. Genet. 36:40-45(2004).
Grimwood J., Nature 428:529-535(2004).<

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A05245 is guaranteed for IHC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Validation Images & Assay Conditions

Gene/Protein Information For URI1 (Source: Uniprot.org, NCBI)

Alternative Names

Unconventional prefoldin RPB5 interactor 1;Protein NNX3;Protein phosphatase 1 regulatory subunit 19;RNA polymerase II subunit 5-mediating protein;RPB5-mediating protein;URI1;C19orf2, NNX3, PPP1R19, RMP, URI; URI1 C19orf2, NNX3, PPP1R19, RMP, URI URI1 prefoldin like chaperone unconventional prefoldin RPB5 interactor 1|RNA polymerase II subunit 5-mediating protein|RPB5-mediating protein|protein phosphatase 1, regulatory subunit 19

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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