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Product Info Summary
| SKU: | A09915-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Rim2 RIMS2 Antibody
SKU/Catalog Number
A09915-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Rim2 RIMS2 Antibody (Catalog # A09915-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Rim2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Rim2 RIMS2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09915-1)
Host
Rabbit
Contents
Rim2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Rim2 antibody was raised against a 17 amino acid synthetic peptide near the center of the human Rim2. The immunogen is located within amino acids 250 - 300 of Rim2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Multiple isoforms of RIM2 are known to exist. This antibody is predicted to have no cross-reactivity to other Rim proteins.
Reactive Species
A09915-1 is reactive to RIMS2 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
160403 MW
Background of RIMS2
Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim 2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A09915-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Rim2 antibody can be used for detection of Rim2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Rim2 in human brain tissue lysate with Rim2 antibody at 1 μg/mL.
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Immunohistochemistry of Rim2 in human brain with Rim2 antibody at 5 μg/mL.
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Immunofluorescence of Rim2 in Human Brain tissue with Rim2 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For RIMS2 (Source: Uniprot.org, NCBI)
Gene Name
RIMS2
Full Name
Regulating synaptic membrane exocytosis protein 2
Weight
160403 MW
Alternative Names
OBOE, RIM2, RAB3IP3, KIAA0751, Regulating synaptic membrane exocytosis protein 2, Rab-3-interacting molecule 2, RIM 2 RIMS2 CRSDS, OBOE, RAB3IP3, RIM2 regulating synaptic membrane exocytosis 2 regulating synaptic membrane exocytosis protein 2|RAB3 interacting protein 3|Rab3-interacting protein|non-small cell lung cancer RimL3a protein|non-small cell lung cancer RimL3c protein|nuclear protein|rab-3-interacting molecule 2|rab-3-interacting protein 3|rab3-interacting molecule 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on RIMS2, check out the RIMS2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for RIMS2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Rim2 RIMS2 Antibody (A09915-1)
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