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Product Info Summary
| SKU: | A03937 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-RABEX5 RABGEF1 Antibody
SKU/Catalog Number
A03937
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-RABEX5 RABGEF1 Antibody (Catalog # A03937). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
RABEX5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-RABEX5 RABGEF1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03937)
Host
Rabbit
Contents
RABEX5 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
RABEX5 antibody was raised against a 19 amino acid synthetic peptide near the center terminus of human RABEX5. The immunogen is located within amino acids 430 - 480 of RABEX5.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least four isoforms of RABEX5 are known to exist; this antibody will recognize all four. RABEX5 antibody is predicted to not cross-react with other LRRFIP family members.
Reactive Species
A03937 is reactive to RABGEF1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
79371 MW
Background of Rabex5
RABEX5 is a guanine nucleotide exchange factor (GEF) that forms a complex with rabaptin-5 and specifically activates Rab5, a small GTPase that plays an essential role in endocytic traffic. RABEX-5 is thought to also interact with another member of the Rab family, Rab22, which targets RABEX5 to early endosomes, allowing it to activate Rab5 and thereby promote Rab5-mediated endosome fusion.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A03937 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
RABEX5 antibody can be used for detection of RABEX5 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of RABEX5 in human liver tissue lysate with RABEX5 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of RABEX5 in mouse brain tissue with RABEX5 antibody at 5 μg/mL.
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Immunofluorescence of RABEX5 in mouse brain tissue with RABEX5 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For RABGEF1 (Source: Uniprot.org, NCBI)
Gene Name
RABGEF1
Full Name
Rab5 GDP/GTP exchange factor
Weight
79371 MW
Alternative Names
RAP1, RABEX5, rabex-5, RAP1 RABGEF1 RABEX5, RAP1, rabex-5 RAB guanine nucleotide exchange factor 1 rab5 GDP/GTP exchange factor|RAB guanine nucleotide exchange factor (GEF) 1|rabaptin-5-associated exchange factor for Rab5
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on RABGEF1, check out the RABGEF1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for RABGEF1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-RABEX5 RABGEF1 Antibody (A03937)
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