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Product Info Summary
| SKU: | A31732 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-PTRF CAVIN1 Antibody
SKU/Catalog Number
A31732
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-PTRF CAVIN1 Antibody (Catalog # A31732). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Storage & Handling
PTRF antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-PTRF CAVIN1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A31732)
Host
Rabbit
Contents
PTRF Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Rabbit polyclonal PTRF antibody was raised against a 19 amino acid peptide near the carboxy terminus of human PTRF. The immunogen is located within amino acids 270 - 320 of PTRF.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms of PTRF are known to exist; this antibody detects all three isoforms. It is predicted to not cross-react with other members of the cavin family.
Reactive Species
A31732 is reactive to PTRF in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
43476 MW
Background of CAVIN1
The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts, regulating rRNA transcription by promoting the dissociation of transcription complexes and the re-initiation of polymerase I on nascent rRNA transcripts. PTRF also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins, translocating from caveolae to the cytoplasm after insulin stimulation. PTRF is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A31732 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
PTRF antibody can be used for detection of PTRF by Western blot at 0.5 - 1 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of PTRF in human spleen tissue lysate with PTRF antibody at (A) 0.5 and (B) 1 μg/mL
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Immunohistochemistry of PTRF in human spleen tissue with PTRF antibody at 5 μg/ml.
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Immunofluorescence of PTRF in human spleen tissue with PTRF antibody at 20 μg/ml.
Protein Target Info & Infographic
Gene/Protein Information For PTRF (Source: Uniprot.org, NCBI)
Gene Name
PTRF
Full Name
Caveolae-associated protein 1
Weight
43476 MW
Superfamily
CAVIN family
Alternative Names
CGL4, CAVIN, CAVIN1, FKSG13, cavin-1, Polymerase I and transcript release factor, Cavin-1 CAVIN1 CAVIN, CGL4, FKSG13, PTRF, cavin-1 caveolae associated protein 1 caveolae-associated protein 1|RNA polymerase I and transcript release factor|TTF-I interacting peptide 12|congenital generalized lipodystrophy 4|polymerase I and transcript release factor
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PTRF, check out the PTRF Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PTRF: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-PTRF CAVIN1 Antibody (A31732)
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