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Product Info Summary
| SKU: | A05405 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-PTPN5 Antibody
SKU/Catalog Number
A05405
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-PTPN5 Antibody (Catalog # A05405). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
PTPN5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-PTPN5 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05405)
Host
Rabbit
Contents
PTPN5 antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
PTPN5 antibody was raised against an 18 amino acid peptide near the amino terminus of human PTPN5. The immunogen is located within amino acids 180 - 230 of PTPN5.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
PTPN5 antibody is human and mouse reactive.
Reactive Species
A05405 is reactive to PTPN5 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
30929 MW
Background of STEP
The protein tyrosine phosphatase PTPN5, also known as Striatal enriched phosphatase (STEP), is involved in the regulation of synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors (1). It is expressed in dopaminoceptive neurons of the central nervous system and multiple forms of PTPN5 show differential enrichment in adult brain regions (2). NMDA-mediated activation of PTPN5 is an important mechanism for regulation of Erk activity in neurons (3). Furthermore, PTPN5 is involved in the regulation of both NMDAR and AMPAR trafficking (4,5). PTPN5 may play a role in Alzheimer's disease (1).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A05405 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
PTPN5 antibody can be used for detection of PTPN5 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of PTPN5 in Jurkat cell lysate with PTPN5 antibody at (A) 1 and (B) 2 μg/ml.
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Immunohistochemistry of PTPN5 in mouse brain tissue with PTPN5 antibody at 5 μg/ml.
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Immunofluorescence of PTPN5 in mouse brain tissue with PTPN5 antibody at 20 μg/ml.
Protein Target Info & Infographic
Gene/Protein Information For PTPN5 (Source: Uniprot.org, NCBI)
Gene Name
PTPN5
Full Name
Tyrosine-protein phosphatase non-receptor type 5
Weight
30929 MW
Superfamily
protein-tyrosine phosphatase family
Alternative Names
Tyrosine-protein phosphatase non-receptor type 5, Neural-specific protein-tyrosine phosphatase, PTPSTEP, Striatum-enriched protein-tyrosine phosphatase, STEP Ptpn5|St, Step|protein tyrosine phosphatase, non-receptor type 5|tyrosine-protein phosphatase non-receptor type 5|neural-specific protein-tyrosine phosphatase|striatum-enriched protein-tyrosine phosphatase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PTPN5, check out the PTPN5 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PTPN5: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-PTPN5 Antibody (A05405)
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