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Product Info Summary
| SKU: | A14691 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-Protein dispatched homolog 2 Disp2 Antibody
SKU/Catalog Number
A14691
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Protein dispatched homolog 2 Disp2 Antibody (Catalog # A14691). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Disp2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Protein dispatched homolog 2 Disp2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A14691)
Host
Rabbit
Contents
Disp2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Disp2 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human Disp2. The immunogen is located within amino acids 1210 - 1260 of Disp2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Two isoforms of PRICKLE4 are known to exist. PRICKLE4 antibody is predicted to not cross-react with other PRICKLE protein family members.
Reactive Species
A14691 is reactive to DISP2 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
152003 MW
Background of DISP2
Disp2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the Disp proteins have been implicated in these pathways. Recently, it has been shown that Disp2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased Disp2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by Disp2 mutants. At least two isoforms of Disp2 are known to exist. This Disp2 antibody is predicted to not cross-react with Disp1 or Disp3.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A14691 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Disp2 antibody can be used for the detection of Disp2 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Disp2 in rat brain tissue lysate with Disp2 antibody at (A) 1 and (B) 2 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For DISP2 (Source: Uniprot.org, NCBI)
Gene Name
DISP2
Full Name
Protein dispatched homolog 2
Weight
152003 MW
Superfamily
dispatched family
Alternative Names
DISPB, HsT16908, DISPB, KIAA1742, Protein dispatched homolog 2 DISP2 C15orf36, DISPB, HsT16908, LINC00594 dispatched RND transporter family member 2 protein dispatched homolog 2|dispatched B|long intergenic non-protein coding RNA 594
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on DISP2, check out the DISP2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for DISP2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Protein dispatched homolog 2 Disp2 Antibody (A14691)
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