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Product Info Summary
| SKU: | A09176-3 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-Precerebellin CBLN1 Antibody
SKU/Catalog Number
A09176-3
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Precerebellin CBLN1 Antibody (Catalog # A09176-3). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Precerebellin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Precerebellin CBLN1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09176-3)
Host
Rabbit
Contents
Precerebellin Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Precerebellin antibody was raised against a 15 amino acid synthetic peptide from the middle of human precerebellin. The immunogen is located within amino acids 50 - 100 of Precerebellin.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of TOM70 are known to exist; this antibody will only detect the larger isoform.
Reactive Species
A09176-3 is reactive to CBLN1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
21097 MW
Background of CBLN1
Precerebellin is the precursor of the brain-specific hexadecapeptide cerebellin, a protein with substantial similarity to the globular region of the B chain of complement component C1q. Cerebellin exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/pka- dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release. The active form of precerebellin is highly enriched in postsynaptic structures of cerebellar Purkinje cells in cartwheel neurons of the dorsal cochlear nucleus. Because precerebellin belongs to the C1q/tumor necrosis factor superfamily of secreted proteins and has similarity to adiponectin and CTRP3, it has been suggested that precerebellin posseses functions other than those already stated.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A09176-3 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Precerebellin antibody can be used for the detection of precerebellin by Western blot at 2 - 4 μg/mL. Antibody can also be used for immunohistochemistry starting at 2 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of precerebellin in mouse cerebellum lysate with precerebellin antibody at (A) 2 and (B) 4 μg/mL.
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Immunohistochemical staining of rat brain tissue using precerebellin antibody at 2 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For CBLN1 (Source: Uniprot.org, NCBI)
Gene Name
CBLN1
Full Name
Cerebellin-1
Weight
21097 MW
Alternative Names
Cerebellin-1, Precerebellin, CER CBLN1 cerebellin 1 precursor cerebellin-1|precerebellin
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CBLN1, check out the CBLN1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CBLN1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Precerebellin CBLN1 Antibody (A09176-3)
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