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Product Info Summary
| SKU: | P06871 |
|---|---|
| Size: | 100 µl |
| Reactive Species: | Hamster, Mouse, Rat |
| Host: | Rabbit |
| Application: | IHC, ICC, WB |
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Product info
Product Name
Anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) Kcnc1 Antibody
View all Potassium Channel Kv3.1 Antibodies
SKU/Catalog Number
P06871
Size
100 µl
Form
Liquid
Description
Boster Bio Anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) Kcnc1 Antibody (Catalog # P06871). Tested in WB, IHC, ICC applications. This antibody reacts with Hamster, Mouse, Rat.
Storage & Handling
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. After date of receipt, stable for at least 1 year at -20°C.
Cite This Product
Anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) Kcnc1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # P06871)
Host
Rabbit
Contents
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Clonality
Polyclonal
Isotype
IgG
Immunogen
The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser503 of the rat voltage-gated potassium channel Kv3.1, conjugated to keyhole limpet hemocyanin (KLH). Immunogen species is Rat.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
P06871 is reactive to KCNC1 in Hamster, Mouse, Rat
Reconstitution
Restore with deionized water (or equivalent) for reconstitution volume of 100 µL
Observed Molecular Weight
52 kDa
Calculated molecular weight
65857 MW
Background of Potassium Channel Kv3.1
Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
P06871 is guaranteed for IHC, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:1000
IHC: 1:400-1:1000
ICC: 1:400
Validation Images & Assay Conditions
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Immunostaining of medial nucleus of the trapezoid body (MNTB) cells with the phospho-Ser503 Kv3.1 subunit antibody. The left panel shows control cells. The right panel shows cells that have been exposed to the protein kinase C activator PMA.
Protein Target Info & Infographic
Gene/Protein Information For KCNC1 (Source: Uniprot.org, NCBI)
Gene Name
KCNC1
Full Name
Potassium voltage-gated channel subfamily C member 1
Weight
65857 MW
Superfamily
potassium channel family
Alternative Names
C230009H10Rik antibody, FLJ41162 antibody, FLJ42249 antibody, FLJ43491 antibody, Kcnc1 antibody, KCNC1 antibody, KCNC1_HUMAN antibody, Kcr2 1 antibody, KShIIIB antibody, Kv3.1 antibody, Kv4 antibody, MGC129855 antibody, NGK2 antibody, Potassium voltage-gated channel subfamily C member 1 antibody, Shaw antibody, Voltage gated potassium channel antibody, Voltage gated potassium channel subunit Kv3.1 antibody, Voltage-gated potassium channel subunit Kv3.1 antibody, Voltage-gated potassium channel subunit Kv4 antibody KCNC1 EPM7, KV3.1, KV4, NGK2 potassium voltage-gated channel subfamily C member 1 potassium voltage-gated channel subfamily C member 1|potassium channel, voltage gated Shaw related subfamily C, member 1|voltage-gated potassium channel protein KV3.1|voltage-gated potassium channel subunit Kv4
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on KCNC1, check out the KCNC1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for KCNC1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) Kcnc1 Antibody (P06871)
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Customer Q&As
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7 Customer Q&As for Anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) Kcnc1 Antibody
Question
Is this P06871 anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) antibody reactive to the isotypes of KCNC1?
Verified Customer
Verified customer
Asked: 2020-05-06
Answer
The immunogen of P06871 anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) antibody is The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser503 of the voltage-gated potassium channel Kv3.1, conjugated to keyhole limpet hemocyanin (KLH). Could you tell me which isotype you are interested in so I can help see if the immunogen is part of this isotype?
Boster Scientific Support
Answered: 2020-05-06
Question
Will anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) antibody P06871 work for IHC with right hemisphere of cerebellum?
Verified Customer
Verified customer
Asked: 2020-02-28
Answer
According to the expression profile of right hemisphere of cerebellum, KCNC1 is highly expressed in right hemisphere of cerebellum. So, it is likely that anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) antibody P06871 will work for IHC with right hemisphere of cerebellum.
Boster Scientific Support
Answered: 2020-02-28
Question
I am looking for to test anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) antibody P06871 on mouse right hemisphere of cerebellum for research purposes, then I may be interested in using anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) antibody P06871 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?
Verified Customer
Verified customer
Asked: 2020-01-29
Answer
The products we sell, including anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) antibody P06871, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.
Boster Scientific Support
Answered: 2020-01-29
Question
We are currently using anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) antibody P06871 for mouse tissue, and we are well pleased with the IHC results. The species of reactivity given in the datasheet says mouse, rat. Is it true that the antibody can work on feline tissues as well?
Verified Customer
Verified customer
Asked: 2019-07-22
Answer
The anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) antibody (P06871) has not been validated for cross reactivity specifically with feline tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in feline you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2019-07-22
Question
Is there a BSA free version of anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) antibody P06871 available?
Verified Customer
Verified customer
Asked: 2018-02-27
Answer
We appreciate your recent telephone inquiry. I can confirm that some lots of this anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) antibody P06871 are BSA free. For now, these lots are available and we can make a BSA free formula for you free of charge. It will take 3 extra days to prepare. If you require this antibody BSA free again in future, please do not hesitate to contact me and I will be pleased to check which lots we have in stock that are BSA free.
Boster Scientific Support
Answered: 2018-02-27
Question
I was wanting to use your anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) antibody for IHC for mouse right hemisphere of cerebellum on frozen tissues, but I want to know if it has been validated for this particular application. Has this antibody been validated and is this antibody a good choice for mouse right hemisphere of cerebellum identification?
Verified Customer
Verified customer
Asked: 2018-01-04
Answer
As indicated on the product datasheet, P06871 anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) antibody has been tested for IHC on mouse, rat tissues. We have an innovator award program that if you test this antibody and show it works in mouse right hemisphere of cerebellum in IHC-frozen, you can get your next antibody for free.
Boster Scientific Support
Answered: 2018-01-04
Question
Will P06871 anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) antibody work on parafin embedded sections? If so, which fixation method do you recommend we use (PFA, paraformaldehyde, other)?
N. Carter
Verified customer
Asked: 2013-08-16
Answer
You can see on the product datasheet, P06871 anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) antibody as been validated on IHC. It is best to use PFA for fixation because it has better tissue penetration ability. PFA needs to be prepared fresh before use. Long term stored PFA turns into formalin, as the PFA molecules congregate and become formalin.
Boster Scientific Support
Answered: 2013-08-16
