Anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) Kcnc1 Antibody

Product Name

Anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) Kcnc1 Antibody

View all Potassium Channel Kv3.1 Antibodies

SKU/Catalog Number

P06871

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) Kcnc1 Antibody (Catalog # P06871). Tested in WB, IHC, ICC applications. This antibody reacts with Hamster, Mouse, Rat.

Storage & Handling

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. After date of receipt, stable for at least 1 year at -20°C.

Cite This Product

Anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) Kcnc1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # P06871)

Host

Rabbit

Contents

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser503 of the rat voltage-gated potassium channel Kv3.1, conjugated to keyhole limpet hemocyanin (KLH). Immunogen species is Rat.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

P06871 is reactive to KCNC1 in Hamster, Mouse, Rat

Applications

P06871 is guaranteed for IHC, ICC, WB Boster Guarantee

Observed Molecular Weight

52 kDa

Calculated molecular weight

65857 MW

Background of Potassium Channel Kv3.1

Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 100 µL

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:1000
IHC: 1:400-1:1000
ICC: 1:400

Validation Images & Assay Conditions

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Immunostaining of medial nucleus of the trapezoid body (MNTB) cells with the phospho-Ser⁵⁰³ Kv3.1 subunit antibody. The left panel shows control cells. The right panel shows cells that have been exposed to the protein kinase C activator PMA.

Gene/Protein Information For KCNC1 (Source: Uniprot.org, NCBI)

Alternative Names

FLJ41162; FLJ42249; FLJ43491; KCNC1; KV3.1; KV4; MGC129855; NGK2; Potassium Channel Kv3.1; potassium voltage-gated channel subfamily C member 1; potassium voltage-gated channel, Shaw-related subfamily, member 1; voltage-gated potassium channel protein KV3.1; Voltage-gated potassium channel subunit Kv3.1; Voltage-gated potassium channel subunit Kv4 KCNC1 EPM7, KV3.1, KV4, NGK2 potassium voltage-gated channel subfamily C member 1 potassium voltage-gated channel subfamily C member 1|potassium channel, voltage gated Shaw related subfamily C, member 1|voltage-gated potassium channel protein KV3.1|voltage-gated potassium channel subunit Kv4

For more info on KCNC1, check out the KCNC1 Infographic

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In this infographic, you will see the following information for KCNC1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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