Anti-Pleiotrophin/PTN Antibody Picoband®

Product Name

Anti-Pleiotrophin/PTN Antibody Picoband®

View all Pleiotrophin/PTN Antibodies

SKU/Catalog Number

PA1414

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Pleiotrophin/PTN Antibody catalog # PA1414. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Pleiotrophin/PTN Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1414)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Pleiotrophin, identical to the related rat and mouse sequences.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1414 is reactive to PTN in Human, Mouse, Rat

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

36 kDa

Calculated molecular weight

18942 MW

Background of Pleiotrophin/PTN

Pleiotrophin (PTN) also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin affinity regulatory peptide (HARP) or heparin binding growth associated molecule (HB-GAM) is a protein that in humans is encoded by the PTN gene. PTN is the first member of a family of developmentally regulated cytokines. The PTN gene is mapped to 7q33-q34. A mutant PTN that contained only the first N-terminal 40 amino acids was a dominant negative. Pleiotrophin is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. Pleiotrophin binds to cell-surface nucleolin as a low affinity receptor. This binding can inhibit HIV infection.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PA1414 is guaranteed for IHC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse

Positive Control

WB: Rat Brain Tissue, Rat Kidney Tissue, MCF-7 Cell, HT1080 Cell, SMMC Cell
IHC: Human Mammary Cancer Tissue

Validation Images & Assay Conditions

Gene/Protein Information For PTN (Source: Uniprot.org, NCBI)

Alternative Names

Pleiotrophin;PTN;Heparin-binding brain mitogen;HBBM;Heparin-binding growth factor 8;HBGF-8;Heparin-binding growth-associated molecule;HB-GAM;Heparin-binding neurite outgrowth-promoting factor 1;HBNF-1;Osteoblast-specific factor 1;OSF-1;PTN;HBNF1, NEGF1; PTN HARP, HB-GAM, HBBM, HBGF-8, HBGF8, HBNF, HBNF-1, NEGF1, OSF-1 pleiotrophin pleiotrophin|heparin affin regulatory protein|heparin-binding brain mitogen|heparin-binding growth factor 8|heparin-binding growth-associated molecule|heparin-binding neurite outgrowth promoting factor|heparin-binding neurite outgrowth-promoting factor 1|osteoblast-specific factor 1|pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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