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Product Info Summary
| SKU: | A17906 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, ICC, WB |
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Product info
Product Name
Anti-PIERCE1 C9orf116 Antibody
SKU/Catalog Number
A17906
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-PIERCE1 C9orf116 Antibody (Catalog # A17906). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse.
Storage & Handling
PIERCE1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-PIERCE1 C9orf116 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A17906)
Host
Rabbit
Contents
PIERCE1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
PIERCE1 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human PIERCE1. The immunogen is located within the first 50 amino acids of PIERCE1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
PIERCE1 antibody is predicted to not cross-react with other UPF0691 family members.
Reactive Species
A17906 is reactive to C9ORF116 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
15260 MW
Background of Pierce-1
PIERCE1, also known as C9orf116, is an important p53 target gene contributing to normal DNA damage response and may play crucial roles in maintaining genomic integrity against genotoxic stresses, including UVC irradiation. PIERCE1 exists as two alternatively spliced isoforms and is predominantly expressed in human small cell lung cancer. PIERCE1 knockdown induces down-regulation of proapoptotic genes including Ei24, Apaf1 and PTEN, suggesting that PIERCE1 is a proapoptotic gene. It is helpful for in-depth understanding of p53 pathways and the design of new cancer therapies.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A17906 is guaranteed for ELISA, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
PIERCE1 antibody can be used for detection of PIERCE1 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of PIERCE1 in A20 cell lysate with PIERCE1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunocytochemistry of PIERCE1 in A20 cells with PIERCE1 antibody at 2.5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For C9ORF116 (Source: Uniprot.org, NCBI)
Gene Name
C9ORF116
Full Name
UPF0691 protein C9orf116
Weight
15260 MW
Superfamily
UPF0691 family
Alternative Names
PIERCE1, RbEST47, UPF0691 protein C9orf116, p53-induced expression in RB-null cells protein 1, Pierce1 C9orf116 PIERCE1, RbEST47 chromosome 9 open reading frame 116 UPF0691 protein C9orf116|p53-induced expression 1 in Rb-/- cells|p53-induced expression 1 in Rba^/a^ cells|p53-induced expression in RB-null cells protein 1|pierce 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on C9ORF116, check out the C9ORF116 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for C9ORF116: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-PIERCE1 C9orf116 Antibody (A17906)
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