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Product Info Summary
| SKU: | A05780 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-PHOX2A Antibody
SKU/Catalog Number
A05780
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-PHOX2A Antibody (Catalog # A05780). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
PHOX2A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-PHOX2A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05780)
Host
Rabbit
Contents
PHOX2A Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
PHOX2A antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human PHOX2A. The immunogen is located within the last 50 amino acids of PHOX2A.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
PHOX2A antibody is predicted to not cross-react with other paired homeobox family members.
Reactive Species
A05780 is reactive to PHOX2A in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
29653 MW
Background of PHOX2A
PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A05780 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
PHOX2A antibody can be used for detection of PHOX2A by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 2.5 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of PHOX2A in rat brain tissue lysate with PHOX2A antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of PHOX2A in human brain tissue with PHOX2A antibody at 2.5 μg/mL.
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Immunofluorescence of PHOX2A in human brain tissue with PHOX2A antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For PHOX2A (Source: Uniprot.org, NCBI)
Gene Name
PHOX2A
Full Name
Paired mesoderm homeobox protein 2A
Weight
29653 MW
Superfamily
paired homeobox family
Alternative Names
ARIX, FEOM2, NCAM2, PMX2A, CFEOM2, ARIX, Paired mesoderm homeobox protein 2A, ARIX1 homeodomain protein PHOX2A ARIX, CFEOM2, FEOM2, NCAM2, PMX2A paired like homeobox 2A paired mesoderm homeobox protein 2A|ARIX1 homeodomain protein|aristaless homeobox homolog|aristaless homeobox protein homolog|arix homeodomain protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PHOX2A, check out the PHOX2A Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PHOX2A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-PHOX2A Antibody (A05780)
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