Product Info Summary
SKU: | A02386Y643 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | ELISA, IHC, WB |
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Product info
Product Name
Anti-Phospho-Gab 2 (Y643) Antibody
SKU/Catalog Number
A02386Y643
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Phospho-Gab 2 (Y643) Antibody catalog # A02386Y643. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Phospho-Gab 2 (Y643) Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02386Y643)
Host
Rabbit
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human Gab 2 around the phosphorylation site of Y643.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A02386Y643 is reactive to GAB2 in Human, Mouse, Rat
Applications
A02386Y643 is guaranteed for ELISA, IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
74458 MW
Background of GAB2
Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.
Aebi M., Mol. Cell. Biol. 9:5062-5072(1989).
Hattori M., Nature 405:311-319(2000).
Mural R.J., Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Validation Images & Assay Conditions
![a02386y643 anti phospho gab 2 y643 antibody ihc testing 1 a02386y643 anti phospho gab 2 y643 antibody ihc testing 1](https://www.bosterbio.com/media/catalog/product/a/0/a02386y643-anti-phospho-gab-2-y643-antibody-ihc-testing-1.jpg)
Click image to see more details
Immunohistochemistry analysis of paraffin-embedded human brain, using Gab2 (Phospho-Tyr643) Antibody. The picture on the right is blocked with the phospho peptide.
Protein Target Info & Infographic
Gene/Protein Information For GAB2 (Source: Uniprot.org, NCBI)
Gene Name
GAB2
Full Name
GRB2-associated-binding protein 2
Weight
74458 MW
Superfamily
GAB family
Alternative Names
GAB2; GRB2-associated binding protein 2; GRB2-associated-binding protein 2; Growth factor receptor bound protein 2-associated protein 2; KIAA0571GRB2-associated binder 2; p100; pp100 GAB2 GRB2 associated binding protein 2 GRB2-associated-binding protein 2|Grb2-associated binder 2|growth factor receptor bound protein 2-associated protein 2|pp100
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GAB2, check out the GAB2 Infographic
![GAB2 infographic](/media/images/gene-infographic-example.jpg)
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GAB2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Phospho-Gab 2 (Y643) Antibody (A02386Y643)
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