Anti-PA28 gamma PSME3 Monoclonal Antibody

Product Name

Anti-PA28 gamma PSME3 Monoclonal Antibody

View all PA28 Activator gamma Subunit/PSME3 Antibodies

SKU/Catalog Number

A04375

Size

100μl

Form

Liquid

Description

Boster Bio Anti-PA28 gamma PSME3 Monoclonal Antibody catalog # A04375. Tested in WB applications. This antibody reacts with Human, Mouse, Pig.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-PA28 gamma PSME3 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04375)

Host

Mouse

Contents

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Clonality

Monoclonal

Clone Number

3F8

Isotype

IgG

Immunogen

Synthesized peptide derived from the Internal region of human PFKM.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A04375 is reactive to PSME3 in Human, Mouse, Pig

Applications

A04375 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

29506 MW

Background of PA28 Activator gamma Subunit/PSME3

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript rTS alpha vary inversely when cell-growth progresses from late-log to plateau phase. Diseases associated with Thymidylate synthase include Rectal Neoplasm and Dihydropyrimidine Dehydrogenase Deficiency. Anti-Thymidylate synthase is useful for researchers interested in Circadian Rhythm, Metabolism and cell cycle research.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:1000-1:2000

Validation Images & Assay Conditions

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Western Blot (WB) analysis using PA28gamma Monoclonal antibody against HepG2, Jurkat, K562 cell lysate.

Gene/Protein Information For PSME3 (Source: Uniprot.org, NCBI)

Alternative Names

11S regulator complex gamma subunit; 11S regulator complex subunit gamma; Activator of multicatalytic protease subunit 3; Ki antigen; Ki; PA28 Activator gamma Subunit; PA28g; PA28gamma; PA28-gamma; PA28GKi nuclear autoantigen; proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); Proteasome activator 28 subunit gamma; proteasome activator 28-gamma; proteasome activator complex subunit 3; PSME3; REG gamma; REG-GAMMA PSME3 HEL-S-283, Ki, PA28-gamma, PA28G, PA28gamma, REG-GAMMA proteasome activator subunit 3 proteasome activator complex subunit 3|11S regulator complex gamma subunit|11S regulator complex subunit gamma|Ki antigen|Ki nuclear autoantigen|PA28 gamma variant 5|REG gamma-3|activator of multicatalytic protease subunit 3|epididymis secretory protein Li 283|proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)|proteasome activator 28 subunit gamma|proteasome activator 28-gamma

For more info on PSME3, check out the PSME3 Infographic

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In this infographic, you will see the following information for PSME3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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