PSME3 Antibodies

AND PSME3 ELISA kits, PSME3 Proteins

Many biological assays use antibodies to detect PSME3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PSME3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PSME3 antibodies...

We validate the specificity of these antibodies to PSME3 by testing them on tissues known to express PSME3 positively and negatively. Browse below to find the PSME3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PSME3 Infographic by Boster Bio

All PSME3 Products

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Product

Figures

Specificity

Applications

Price

Anti-PA28 gamma PSME3 Monoclonal Antibody

12 Q&As

Human, Mouse, Pig

$399
Cat # A04375
100μl

Human PA28 Activator gamma Subunit Recombinant Protein

SDS-PAGE

$250
Cat # PROTP61289
Starting from 10ug

PSME3 (NM_005789) Human Over-expression Lysate

Human

$628
Cat # LS010197
100 µg

PSME3 Overview

Facts about Proteasome activator complex subunit 3.

PSME3 3D structure. Source: alphafold

Proteasome activator complex subunit 3 (PSME3)

Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits.

Facilitates the MDM2-p53/TP53 interaction that promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.

Gene Information

Human
Gene Name:	PSME3
Uniprot:	P61289
Entrez:	10197

Family

Belongs to:

PA28 family

Alternative Names

11S regulator complex gamma subunit; 11S regulator complex subunit gamma; Activator of multicatalytic protease subunit 3; Ki antigen; Ki; PA28 Activator gamma Subunit; PA28g; PA28gamma; PA28-gamma; PA28GKi nuclear autoantigen; proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); Proteasome activator 28 subunit gamma; proteasome activator 28-gamma; proteasome activator complex subunit 3; PSME3; REG gamma; REG-GAMMA

Molecular Weight

Mass (kDA):
29.506 kDA

Genomic Context


Human

Location:	17q21.31
Sequence:	17; NC_000017.11 (42833397..42843760)

Subcellular Localizations

Nucleus. Cytoplasm. Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase.

Diseases

Neoplasms
Malignant Neoplasms
Tissue Adhesions
Diabetes Mellitus
Intestinal Diseases
Insulin Resistance
Diabetes Mellitus, Non-insulin-dependent
Metabolic Syndrome X
Colorectal Neoplasms

Acute Promyelocytic Leukemia
Leukemia
Colorectal Cancer
Alzheimer's Disease

Interacting Proteins

ATN1
BBS2
COIL
EAF1
EAF2

FBXO7
MDM2
NCOA3
PFDN5
PRKAB2

PRR13
SMURF1
SPG7
TNFAIP8L1
TP53

TXN2
WDYHV1
ZCCHC10

Pathways

Cell Cycle
Proteolysis
Localization
Dna Damage Checkpoint
Cognition
Catabolic Process

PTMs

Phosphorylation

Cleavage

Research Areas

Core ESC-Like Genes
Immune System Diseases
Immunology
Neuroscience
Stem Cell Markers

Ubiquitin Proteasome Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSME3

References

PMID: 1968796 by Nikaido T., et al. Cloning and nucleotide sequence of cDNA for Ki antigen, a highly conserved nuclear protein detected with sera from patients with systemic lupus erythematosus.

PMID: 7951316 by Albertsen H.M., et al. A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21.