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Product Info Summary
| SKU: | A13037-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-p53AIP1 TP53AIP1 Antibody
SKU/Catalog Number
A13037-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-p53AIP1 TP53AIP1 Antibody (Catalog # A13037-1). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.
Storage & Handling
p53AIP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-p53AIP1 TP53AIP1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A13037-1)
Host
Rabbit
Contents
p53AIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
p53AIP1 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human p53AIP1. The immunogen is located within the first 50 amino acids of p53AIP1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
GBP6 antibody is predicted to not cross-react with other GBP family members.
Reactive Species
A13037-1 is reactive to TP53AIP1 in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
12935 MW
Background of p53 AIP1
The p53 tumor-suppressor protein can induce apoptosis through transcriptional activation of several genes. One such protein p53AIP was initially identified through direct cloning of p53 binding sequences from human genomic DNA. Its expression is inducible by p53 following p53 phosphorylation on Ser-46, and ectopic expression of p53AIP leads to apoptotic cell death. Both the phosphorylation of p53 and the induction of p53AIP were blocked by inhibiting the expression of p53DINP1 by the introduction of antisense oligonucleotides to p53DINP1, suggesting that the apoptosis associated with p53AIP expression is regulated by p53DINP1. Finally, as adenovirus-mediated introduction of p53AIP has been shown to suppress tumor growth in vivo, it has been suggested that p53AIP gene transfer may become a useful strategy for the treatment of p53-resistant cancers. Three isoforms of p53AIP are known to exist; this antibody will detect all three.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A13037-1 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
p53AIP1 antibody can be used for detection of p53AIP1 by Western blot at 4 - 8 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of p53AIP1 in HL60 cell lysate with p53AIP1 antibody at (A) 4 and (B) 8 μg/mL.
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Immunocytochemistry of p53AIP1 in HL60 cells with p53AIP1 antibody at 10 μg/mL.
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Immunofluorescence of p53AIP1 in HL60 cells with p53AIP1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TP53AIP1 (Source: Uniprot.org, NCBI)
Gene Name
TP53AIP1
Full Name
p53-regulated apoptosis-inducing protein 1
Weight
12935 MW
Alternative Names
P53AIP1, p53-regulated apoptosis-inducing protein 1, p53AIP1 TP53AIP1 P53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 p53-regulated apoptosis-inducing protein 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TP53AIP1, check out the TP53AIP1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TP53AIP1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-p53AIP1 TP53AIP1 Antibody (A13037-1)
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