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Product Info Summary
| SKU: | A10668 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-NPAS3 Antibody
SKU/Catalog Number
A10668
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-NPAS3 Antibody (Catalog # A10668). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
NPAS3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-NPAS3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10668)
Host
Rabbit
Contents
NPAS3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
NPAS3 antibody was raised against a 28 amino acid synthetic peptide from near the amino terminus of human NPAS3. The immunogen is located within amino acids 40 - 90 of NPAS3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms of MTERFD2 are known to exist. MTERFD2 antibody is predicted to not cross-react with other MTERFD protein family members.
Reactive Species
A10668 is reactive to NPAS3 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
100805 MW
Background of Npas3
Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia. It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region. NPAS3-null mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities. Furthermore, these NPAS3-null mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin. These results demonstrate the essential role played by NPAS3 during structural and functional brain development. At least three isoforms of NPAS3 are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A10668 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
NPAS3 antibody can be used for detection of NPAS3 by Western blot at 0.5 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of NPAS3 in SK-N-SH cell lysate with NPAS3 antibody at (A) 0.5
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Immunohistochemistry of NPAS3 in human brain tissue with NPAS3 antibody at 5 μg/mL.
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Immunofluorescence of NPAS3 in human brain tissue with NPAS3 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For NPAS3 (Source: Uniprot.org, NCBI)
Gene Name
NPAS3
Full Name
Neuronal PAS domain-containing protein 3
Weight
100805 MW
Alternative Names
MOP6, PASD6, bHLHe12, BHLHE12, MOP6, Neuronal PAS domain-containing protein 3, Basic-helix-loop-helix-PAS protein MOP6, Neuronal PAS3 Npas3|4930423H22Rik, bHLHe1, bHLHe12|neuronal PAS domain protein 3|neuronal PAS domain-containing protein 3|basic-helix-loop-helix-PAS protein MOP6|member of PAS protein 6|neuronal PAS3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on NPAS3, check out the NPAS3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for NPAS3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-NPAS3 Antibody (A10668)
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